Microbial co-occurrences on catheters from long-term catheterized patients

Taylor M. Nye, Zongsen Zou, Chloe L. P. Obernuefemann, Jerome S. Pinkner, Erin Lowry, Kent Kleinschmidt, Karla Bergeron, Aleksandra Klim, Karen W. Dodson, Ana L. Flores-Mireles, Jennifer N. Walker, Daniel Garrett Wong, Alana Desai, Michael G. Caparon () and Scott J. Hultgren ()
Additional contact information
Taylor M. Nye: Washington University School of Medicine
Zongsen Zou: Washington University School of Medicine
Chloe L. P. Obernuefemann: Washington University School of Medicine
Jerome S. Pinkner: Washington University School of Medicine
Erin Lowry: Washington University School of Medicine
Kent Kleinschmidt: Washington University School of Medicine
Karla Bergeron: Washington University School of Medicine
Aleksandra Klim: Washington University School of Medicine
Karen W. Dodson: Washington University School of Medicine
Ana L. Flores-Mireles: University of Notre Dame
Jennifer N. Walker: The University of Texas Health Science Center
Daniel Garrett Wong: Washington University School of Medicine
Alana Desai: Washington University School of Medicine
Michael G. Caparon: Washington University School of Medicine
Scott J. Hultgren: Washington University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Catheter-associated urinary tract infections (CAUTIs), a common cause of healthcare-associated infections, are caused by a diverse array of pathogens that are increasingly becoming antibiotic resistant. We analyze the microbial occurrences in catheter and urine samples from 55 human long-term catheterized patients collected over one year. Although most of these patients were prescribed antibiotics over several collection periods, their catheter samples remain colonized by one or more bacterial species. Examination of a total of 366 catheter and urine samples identify 13 positive and 13 negative genus co-occurrences over 12 collection periods, representing associations that occur more or less frequently than expected by chance. We find that for many patients, the microbial species composition between collection periods is similar. In a subset of patients, we find that the most frequently sampled bacteria, Escherichia coli and Enterococcus faecalis, co-localize on catheter samples. Further, co-culture of paired isolates recovered from the same patients reveals that E. coli significantly augments E. faecalis growth in an artificial urine medium, where E. faecalis monoculture grows poorly. These findings suggest novel strategies to collapse polymicrobial CAUTI in long-term catheterized patients by targeting mechanisms that promote positive co-associations.

Date: 2024
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-44095-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44095-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-44095-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().