Integrative single-cell characterization of a frugivorous and an insectivorous bat kidney and pancreas

Wei E. Gordon, Seungbyn Baek, Hai P. Nguyen, Yien-Ming Kuo, Rachael Bradley, Sarah L. Fong, Nayeon Kim, Alex Galazyuk, Insuk Lee, Melissa R. Ingala, Nancy B. Simmons, Tony Schountz, Lisa Noelle Cooper, Ilias Georgakopoulos-Soares, Martin Hemberg () and Nadav Ahituv ()
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Wei E. Gordon: University of California, San Francisco
Seungbyn Baek: Yonsei University
Hai P. Nguyen: University of California, San Francisco
Yien-Ming Kuo: University of California, San Francisco
Rachael Bradley: University of California, San Francisco
Sarah L. Fong: University of California, San Francisco
Nayeon Kim: Yonsei University
Alex Galazyuk: Northeast Ohio Medical University
Insuk Lee: Yonsei University
Melissa R. Ingala: Fairleigh Dickinson University
Nancy B. Simmons: American Museum of Natural History
Tony Schountz: Colorado State University
Lisa Noelle Cooper: Northeast Ohio Medical University
Ilias Georgakopoulos-Soares: The Pennsylvania State University College of Medicine
Martin Hemberg: Brigham and Women’s Hospital and Harvard Medical School
Nadav Ahituv: University of California, San Francisco

Nature Communications, 2024, vol. 15, issue 1, 1-23

Abstract: Abstract Frugivory evolved multiple times in mammals, including bats. However, the cellular and molecular components driving it remain largely unknown. Here, we use integrative single-cell sequencing (scRNA-seq and scATAC-seq) on insectivorous (Eptesicus fuscus; big brown bat) and frugivorous (Artibeus jamaicensis; Jamaican fruit bat) bat kidneys and pancreases and identify key cell population, gene expression and regulatory differences associated with the Jamaican fruit bat that also relate to human disease, particularly diabetes. We find a decrease in loop of Henle and an increase in collecting duct cells, and differentially active genes and regulatory elements involved in fluid and electrolyte balance in the Jamaican fruit bat kidney. The Jamaican fruit bat pancreas shows an increase in endocrine and a decrease in exocrine cells, and differences in genes and regulatory elements involved in insulin regulation. We also find that these frugivorous bats share several molecular characteristics with human diabetes. Combined, our work provides insights from a frugivorous mammal that could be leveraged for therapeutic purposes.

Date: 2024
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DOI: 10.1038/s41467-023-44186-y

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