Distinct mesenchymal cell states mediate prostate cancer progression

Hubert Pakula, Mohamed Omar, Ryan Carelli, Filippo Pederzoli, Giuseppe Nicolò Fanelli, Tania Pannellini, Fabio Socciarelli, Lucie Van Emmenis, Silvia Rodrigues, Caroline Fidalgo-Ribeiro, Pier Vitale Nuzzo, Nicholas J. Brady, Wikum Dinalankara, Madhavi Jere, Itzel Valencia, Christopher Saladino, Jason Stone, Caitlin Unkenholz, Richard Garner, Mohammad K. Alexanderani, Francesca Khani, Francisca Nunes Almeida, Cory Abate-Shen, Matthew B. Greenblatt, David S. Rickman, Christopher E. Barbieri, Brian D. Robinson, Luigi Marchionni and Massimo Loda ()
Additional contact information
Hubert Pakula: Weill Cornell Medicine
Mohamed Omar: Weill Cornell Medicine
Ryan Carelli: Weill Cornell Medicine
Filippo Pederzoli: Weill Cornell Medicine
Giuseppe Nicolò Fanelli: Weill Cornell Medicine
Tania Pannellini: Weill Cornell Medicine
Fabio Socciarelli: Weill Cornell Medicine
Lucie Van Emmenis: Weill Cornell Medicine
Silvia Rodrigues: Weill Cornell Medicine
Caroline Fidalgo-Ribeiro: Weill Cornell Medicine
Pier Vitale Nuzzo: Weill Cornell Medicine
Nicholas J. Brady: Weill Cornell Medicine
Wikum Dinalankara: Weill Cornell Medicine
Madhavi Jere: Weill Cornell Medicine
Itzel Valencia: Weill Cornell Medicine
Christopher Saladino: Weill Cornell Medicine
Jason Stone: Weill Cornell Medicine
Caitlin Unkenholz: Weill Cornell Medicine
Richard Garner: Weill Cornell Medicine
Mohammad K. Alexanderani: Weill Cornell Medicine
Francesca Khani: Weill Cornell Medicine
Francisca Nunes Almeida: Columbia University Irving Medical Center
Cory Abate-Shen: Columbia University Irving Medical Center
Matthew B. Greenblatt: Weill Cornell Medicine
David S. Rickman: Weill Cornell Medicine
Christopher E. Barbieri: Weill Cornell Medicine, Belfer Research Building
Brian D. Robinson: Weill Cornell Medicine
Luigi Marchionni: Weill Cornell Medicine
Massimo Loda: Weill Cornell Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-21

Abstract: Abstract In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular changes in tumor stroma that influence PCa progression and metastasis. Analyzing mesenchymal cells from four genetically engineered mouse models (GEMMs) and correlating these findings with human tumors, we identify eight stromal cell populations with distinct transcriptional identities consistent across both species. Notably, stromal signatures in advanced mouse disease reflect those in human bone metastases, highlighting periostin’s role in invasion and differentiation. From these insights, we derive a gene signature that predicts metastatic progression in localized disease beyond traditional Gleason scores. Our results illuminate the critical influence of stromal dynamics on PCa progression, suggesting new prognostic tools and therapeutic targets.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44210-1

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DOI: 10.1038/s41467-023-44210-1

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