The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell

Jeong Han Lee, Maria C. Perez-Flores, Seojin Park, Hyo Jeong Kim, Yingying Chen, Mincheol Kang, Jennifer Kersigo, Jinsil Choi, Phung N. Thai, Ryan L. Woltz, Dolores Columba Perez-Flores, Guy Perkins, Choong-Ryoul Sihn, Pauline Trinh, Xiao-Dong Zhang, Padmini Sirish, Yao Dong, Wayne Wei Feng, Isaac N. Pessah, Rose E. Dixon, Bernd Sokolowski, Bernd Fritzsch, Nipavan Chiamvimonvat and Ebenezer N. Yamoah ()
Additional contact information
Jeong Han Lee: University of Nevada
Maria C. Perez-Flores: University of Nevada
Seojin Park: University of Nevada
Hyo Jeong Kim: University of Nevada
Yingying Chen: University of Nevada
Mincheol Kang: University of Nevada
Jennifer Kersigo: University of Iowa
Jinsil Choi: University of Nevada
Phung N. Thai: University of California
Ryan L. Woltz: University of California
Dolores Columba Perez-Flores: University of Nevada
Guy Perkins: University of California San Diego
Choong-Ryoul Sihn: University of Nevada
Pauline Trinh: University of California
Xiao-Dong Zhang: University of California
Padmini Sirish: University of California
Yao Dong: University of California
Wayne Wei Feng: University of California
Isaac N. Pessah: University of California
Rose E. Dixon: Tupper Hall
Bernd Sokolowski: University of South Florida
Bernd Fritzsch: University of Iowa
Nipavan Chiamvimonvat: University of California
Ebenezer N. Yamoah: University of Nevada

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components. The Pz channels, expressed in HC stereocilia, and cell lines are co-localized and co-assembled with MET complex partners. Mice expressing non-functional Pz1 and Pz2 at the ROSA26 locus have impaired auditory and vestibular traits that can only be explained if the Pzs are integral to the MET complex. We suggest that Pz subunits constitute part of the MET complex and that interactions with other MET complex components yield functional MET units to generate HC MET currents.

Date: 2024
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DOI: 10.1038/s41467-023-44230-x

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