Awake ripples enhance emotional memory encoding in the human brain

Haoxin Zhang (), Ivan Skelin, Shiting Ma, Michelle Paff, Lilit Mnatsakanyan, Michael A. Yassa, Robert T. Knight and Jack J. Lin ()
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Haoxin Zhang: University of California Irvine
Ivan Skelin: Toronto Western Hospital, Toronto
Shiting Ma: University of California Irvine
Michelle Paff: University of California Irvine
Lilit Mnatsakanyan: University of California Irvine
Michael A. Yassa: University of California Irvine
Robert T. Knight: University of California Berkeley
Jack J. Lin: School of Medicine, University of California Davis

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Enhanced memory for emotional experiences is hypothesized to depend on amygdala-hippocampal interactions during memory consolidation. Here we show using intracranial recordings from the human amygdala and the hippocampus during an emotional memory encoding and discrimination task increased awake ripples after encoding of emotional, compared to neutrally-valenced stimuli. Further, post-encoding ripple-locked stimulus similarity is predictive of later memory discrimination. Ripple-locked stimulus similarity appears earlier in the amygdala than in hippocampus and mutual information analysis confirms amygdala influence on hippocampal activity. Finally, the joint ripple-locked stimulus similarity in the amygdala and hippocampus is predictive of correct memory discrimination. These findings provide electrophysiological evidence that post-encoding ripples enhance memory for emotional events.

Date: 2024
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DOI: 10.1038/s41467-023-44295-8

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