Neoadjuvant camrelizumab and apatinib combined with chemotherapy versus chemotherapy alone for locally advanced gastric cancer: a multicenter randomized phase 2 trial

Jian-Xian Lin, Yi-Hui Tang, Hua-Long Zheng, Kai Ye, Jian-Chun Cai, Li-Sheng Cai, Wei Lin, Jian-Wei Xie, Jia-Bin Wang, Jun Lu, Qi-Yue Chen, Long-Long Cao, Chao-Hui Zheng, Ping Li () and Chang-Ming Huang ()
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Jian-Xian Lin: Fujian Medical University Union Hospital
Yi-Hui Tang: Fujian Medical University Union Hospital
Hua-Long Zheng: Fujian Medical University Union Hospital
Kai Ye: Second Affiliated Hospital of Fujian Medical University
Jian-Chun Cai: Zhongshan Hospital of Xiamen University
Li-Sheng Cai: Zhangzhou Municipal Hospital of Fujian Province
Wei Lin: The Affiliated Hospital of Putian University
Jian-Wei Xie: Fujian Medical University Union Hospital
Jia-Bin Wang: Fujian Medical University Union Hospital
Jun Lu: Fujian Medical University Union Hospital
Qi-Yue Chen: Fujian Medical University Union Hospital
Long-Long Cao: Fujian Medical University Union Hospital
Chao-Hui Zheng: Fujian Medical University Union Hospital
Ping Li: Fujian Medical University Union Hospital
Chang-Ming Huang: Fujian Medical University Union Hospital

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Prospective evidence regarding the combination of programmed cell death (PD)−1 and angiogenesis inhibitors in treating locally advanced gastric cancer (LAGC) is limited. In this multicenter, randomized, phase 2 trial (NCT04195828), patients with gastric adenocarcinoma (clinical T2-4N + M0) were randomly assigned (1:1) to receive neoadjuvant camrelizumab and apatinib combined with nab-paclitaxel plus S-1 (CA-SAP) or chemotherapy SAP alone (SAP) for 3 cycles. The primary endpoint was the major pathological response (MPR), defined as

Date: 2024
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DOI: 10.1038/s41467-023-44309-5

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