Gut microbiota facilitate chronic spontaneous urticaria

Lei Zhu, Xingxing Jian, Bingjing Zhou, Runqiu Liu, Melba Muñoz, Wan Sun, Lu Xie, Xiang Chen, Cong Peng, Marcus Maurer () and Jie Li ()
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Lei Zhu: Central South University
Xingxing Jian: Central South University
Bingjing Zhou: Central South University
Runqiu Liu: Yancheng Clinical College of Xuzhou Medical University
Melba Muñoz: Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Wan Sun: BGI, Complex building, Beishan Industrial Zone, Yantian District
Lu Xie: Central South University
Xiang Chen: Central South University
Cong Peng: Central South University
Marcus Maurer: Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin
Jie Li: Central South University

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Chronic spontaneous urticaria (CSU) comes with gut dysbiosis, but its relevance remains elusive. Here we use metagenomics sequencing and short-chain fatty acids metabolomics and assess the effects of human CSU fecal microbial transplantation, Klebsiella pneumoniae, Roseburia hominis, and metabolites in vivo. CSU gut microbiota displays low diversity and short-chain fatty acids production, but high gut Klebsiella pneumoniae levels, negatively correlates with blood short-chain fatty acids levels and links to high disease activity. Blood lipopolysaccharide levels are elevated, link to rapid disease relapse, and high gut levels of conditional pathogenic bacteria. CSU microbiome transfer and Klebsiella pneumoniae transplantation facilitate IgE-mediated mast cell(MC)-driven skin inflammatory responses and increase intestinal permeability and blood lipopolysaccharide accumulation in recipient mice. Transplantation of Roseburia hominis and caproate administration protect recipient mice from MC-driven skin inflammation. Here, we show gut microbiome alterations, in CSU, may reduce short-chain fatty acids and increase lipopolysaccharide levels, respectively, and facilitate MC-driven skin inflammation.

Date: 2024
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DOI: 10.1038/s41467-023-44373-x

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