Secreted IgM modulates IL-10 expression in B cells

Shannon Eileen McGettigan, Lazaro Emilio Aira, Gaurav Kumar, Romain Ballet, Eugene C. Butcher, Nicole Baumgarth and Gudrun F. Debes ()
Additional contact information
Shannon Eileen McGettigan: Thomas Jefferson University
Lazaro Emilio Aira: Thomas Jefferson University
Gaurav Kumar: Thomas Jefferson University
Romain Ballet: Veterans Affairs Palo Alto Health Care System
Eugene C. Butcher: Veterans Affairs Palo Alto Health Care System
Nicole Baumgarth: University of California Davis
Gudrun F. Debes: Thomas Jefferson University

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract IL-10+ B cells are critical for immune homeostasis and restraining immune responses in infection, cancer, and inflammation; however, the signals that govern IL-10+ B cell differentiation are ill-defined. Here we find that IL-10+ B cells expand in mice lacking secreted IgM ((s)IgM–/–) up to 10-fold relative to wildtype (WT) among all major B cell and regulatory B cell subsets. The IL-10+ B cell increase is polyclonal and presents within 24 hours of birth. In WT mice, sIgM is produced prenatally and limits the expansion of IL-10+ B cells. Lack of the high affinity receptor for sIgM, FcμR, in B cells translates into an intermediate IL-10+ B cell phenotype relative to WT or sIgM–/– mice. Our study thus shows that sIgM regulates IL-10 programming in B cells in part via B cell-expressed FcμR, thereby revealing a function of sIgM in regulating immune homeostasis.

Date: 2024
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-023-44382-w Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44382-w

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-44382-w

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().