Longevity interventions modulate mechanotransduction and extracellular matrix homeostasis in C. elegans

Alina C. Teuscher, Cyril Statzer, Anita Goyala, Seraina A. Domenig, Ingmar Schoen, Max Hess, Alexander M. Hofer, Andrea Fossati, Viola Vogel, Orcun Goksel, Ruedi Aebersold and Collin Y. Ewald ()
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Alina C. Teuscher: ETH Zürich
Cyril Statzer: ETH Zürich
Anita Goyala: ETH Zürich
Seraina A. Domenig: ETH Zürich
Ingmar Schoen: Irish Centre for Vascular Biology, Royal College of Surgeons in Ireland
Max Hess: ETH Zürich
Alexander M. Hofer: ETH Zürich
Andrea Fossati: ETH Zürich
Viola Vogel: ETH Zürich
Orcun Goksel: ETH Zürich
Ruedi Aebersold: ETH Zürich
Collin Y. Ewald: ETH Zürich

Nature Communications, 2024, vol. 15, issue 1, 1-20

Abstract: Abstract Dysfunctional extracellular matrices (ECM) contribute to aging and disease. Repairing dysfunctional ECM could potentially prevent age-related pathologies. Interventions promoting longevity also impact ECM gene expression. However, the role of ECM composition changes in healthy aging remains unclear. Here we perform proteomics and in-vivo monitoring to systematically investigate ECM composition (matreotype) during aging in C. elegans revealing three distinct collagen dynamics. Longevity interventions slow age-related collagen stiffening and prolong the expression of collagens that are turned over. These prolonged collagen dynamics are mediated by a mechanical feedback loop of hemidesmosome-containing structures that span from the exoskeletal ECM through the hypodermis, basement membrane ECM, to the muscles, coupling mechanical forces to adjust ECM gene expression and longevity via the transcriptional co-activator YAP-1 across tissues. Our results provide in-vivo evidence that coordinated ECM remodeling through mechanotransduction is required and sufficient to promote longevity, offering potential avenues for interventions targeting ECM dynamics.

Date: 2024
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DOI: 10.1038/s41467-023-44409-2

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