Alveolar macrophage-expressed Plet1 is a driver of lung epithelial repair after viral pneumonia

Learta Pervizaj-Oruqaj, Balachandar Selvakumar, Maximiliano Ruben Ferrero, Monika Heiner, Christina Malainou, Rolf David Glaser, Jochen Wilhelm, Marek Bartkuhn, Astrid Weiss, Ioannis Alexopoulos, Biruta Witte, Stefan Gattenlöhner, István Vadász, Rory Edward Morty, Werner Seeger, Ralph Theo Schermuly, Ana Ivonne Vazquez-Armendariz and Susanne Herold ()
Additional contact information
Learta Pervizaj-Oruqaj: University Hospital Giessen, Justus Liebig University, Member of the German Center for Lung Research (DZL)
Balachandar Selvakumar: University Hospital Giessen, Justus Liebig University, Member of the German Center for Lung Research (DZL)
Maximiliano Ruben Ferrero: University Hospital Giessen, Justus Liebig University, Member of the German Center for Lung Research (DZL)
Monika Heiner: University Hospital Giessen, Justus Liebig University, Member of the German Center for Lung Research (DZL)
Christina Malainou: University Hospital Giessen, Justus Liebig University, Member of the German Center for Lung Research (DZL)
Rolf David Glaser: Justus Liebig University
Jochen Wilhelm: Justus Liebig University
Marek Bartkuhn: Justus Liebig University
Astrid Weiss: Excellence Cluster Cardio-Pulmonary Institute (CPI)
Ioannis Alexopoulos: University Hospital Giessen, Justus Liebig University, Member of the German Center for Lung Research (DZL)
Biruta Witte: University Hospital of Giessen
Stefan Gattenlöhner: University Hospital of Giessen
István Vadász: Justus Liebig University
Rory Edward Morty: University Hospital Heidelberg, Member of the German Center for Lung Research (DZL)
Werner Seeger: Justus Liebig University
Ralph Theo Schermuly: Justus Liebig University
Ana Ivonne Vazquez-Armendariz: University Hospital Giessen, Justus Liebig University, Member of the German Center for Lung Research (DZL)
Susanne Herold: University Hospital Giessen, Justus Liebig University, Member of the German Center for Lung Research (DZL)

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract Influenza A virus (IAV) infection mobilizes bone marrow-derived macrophages (BMDM) that gradually undergo transition to tissue-resident alveolar macrophages (TR-AM) in the inflamed lung. Combining high-dimensional single-cell transcriptomics with complex lung organoid modeling, in vivo adoptive cell transfer, and BMDM-specific gene targeting, we found that transitioning (“regenerative”) BMDM and TR-AM highly express Placenta-expressed transcript 1 (Plet1). We reveal that Plet1 is released from alveolar macrophages, and acts as important mediator of macrophage-epithelial cross-talk during lung repair by inducing proliferation of alveolar epithelial cells and re-sealing of the epithelial barrier. Intratracheal administration of recombinant Plet1 early in the disease course attenuated viral lung injury and rescued mice from otherwise fatal disease, highlighting its therapeutic potential.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-023-44421-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44421-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-023-44421-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().