A light-activatable theranostic combination for ratiometric hypoxia imaging and oxygen-deprived drug activity enhancement

Lei Ge, Yikai Tang, Chongzhi Wang, Jian Chen, Hui Mao and Xiqun Jiang ()
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Lei Ge: Nanjing University
Yikai Tang: Nanjing University
Chongzhi Wang: Nanjing University
Jian Chen: Nanjing University
Hui Mao: Emory University
Xiqun Jiang: Nanjing University

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract While performing oxygen-related tumour treatments such as chemotherapy and photodynamic therapy, real-time monitoring hypoxia of tumour is of great value and significance. Here, we design a theranostic combination for light-activated ratiometric hypoxia imaging, hypoxia modulating and prodrug activation. This combination consisted of an oxygen-sensitive near-infrared-emitting ratiometric phosphorescence probe and a hypoxia-activated prodrug-loaded covalent organic framework. In this combination, the probe plays two roles, including quantitative monitoring of oxygen concentration by ratiometric imaging and consuming the oxygen of tumour under light excitation by photodynamic therapy. Meanwhile, the enhanced hypoxia microenvironment of tumour can raise the cytotoxicity of prodrug loaded in covalent organic framework, resulting in boosting antitumour therapeutic effects in vivo. This theranostic combination can precisely provide therapeutic regime and screen hypoxia-activated prodrugs based on real-time tumour hypoxia level, offering a strategy to develop hypoxia mediated tumour theranostics with hypoxia targeted prodrugs.

Date: 2024
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DOI: 10.1038/s41467-023-44429-y

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