Heparin-network-mediated long-lasting coatings on intravascular catheters for adaptive antithrombosis and antibacterial infection

Lin Liu, Huan Yu, Lei Wang, Dongfang Zhou, Xiaozheng Duan, Xu Zhang, Jinghua Yin, Shifang Luan () and Hengchong Shi ()
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Lin Liu: Chinese Academy of Sciences
Huan Yu: Chinese Academy of Sciences
Lei Wang: Chinese Academy of Sciences
Dongfang Zhou: Southern Medical University
Xiaozheng Duan: Chinese Academy of Sciences
Xu Zhang: Chinese Academy of Sciences
Jinghua Yin: Chinese Academy of Sciences
Shifang Luan: Chinese Academy of Sciences
Hengchong Shi: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Bacteria-associated infections and thrombosis, particularly catheter-related bloodstream infections and catheter-related thrombosis, are life-threatening complications. Herein, we utilize a concise assembly of heparin sodium with organosilicon quaternary ammonium surfactant to fabricate a multifunctional coating complex. In contrast to conventional one-time coatings, the complex attaches to medical devices with arbitrary shapes and compositions through a facile dipping process and further forms robust coatings to treat catheter-related bloodstream infections and thrombosis simultaneously. Through their robustness and adaptively dissociation, coatings not only exhibit good stability under extreme conditions but also significantly reduce thrombus adhesion by 60%, and shows broad-spectrum antibacterial activity ( > 97%) in vitro and in vivo. Furthermore, an ex vivo rabbit model verifies that the coated catheter has the potential to prevent catheter-related bacteremia during implantation. This substrate-independent and portable long-lasting multifunctional coating can be employed to meet the increasing clinical demands for combating catheter-related bloodstream infections and thrombosis.

Date: 2024
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DOI: 10.1038/s41467-023-44478-3

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