Single-sided magnetic resonance-based sensor for point-of-care evaluation of muscle

Sydney E. Sherman, Alexa S. Zammit, Won-Seok Heo, Matthew S. Rosen and Michael J. Cima ()
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Sydney E. Sherman: Harvard-MIT Program in Health Science and Technology, Massachusetts Institute of Technology
Alexa S. Zammit: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Won-Seok Heo: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
Matthew S. Rosen: Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital
Michael J. Cima: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract Magnetic resonance imaging is a widespread clinical tool for the detection of soft tissue morphology and pathology. However, the clinical deployment of magnetic resonance imaging scanners is ultimately limited by size, cost, and space constraints. Here, we discuss the design and performance of a low-field single-sided magnetic resonance sensor intended for point-of-care evaluation of skeletal muscle in vivo. The 11 kg sensor has a penetration depth of >8 mm, which allows for an accurate analysis of muscle tissue and can avoid signal from more proximal layers, including subcutaneous adipose tissue. Low operational power and shielding requirements are achieved through the design of a permanent magnet array and surface transceiver coil. The sensor can acquire high signal-to-noise measurements in minutes, making it practical as a point-of-care tool for many quantitative diagnostic measurements, including T2 relaxometry. In this work, we present the in vitro and human in vivo performance of the device for muscle tissue evaluation.

Date: 2024
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DOI: 10.1038/s41467-023-44561-9

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