Electrostatic catalysis of a click reaction in a microfluidic cell

Semih Sevim, Roger Sanchis-Gual, Carlos Franco, Albert C. Aragonès, Nadim Darwish, Donghoon Kim, Rosaria Anna Picca, Bradley J. Nelson, Eliseo Ruiz, Salvador Pané (), Ismael Díez-Pérez () and Josep Puigmartí-Luis ()
Additional contact information
Semih Sevim: ETH Zurich
Roger Sanchis-Gual: ETH Zurich
Carlos Franco: ETH Zurich
Albert C. Aragonès: University of Barcelona (UB)
Nadim Darwish: Curtin University
Donghoon Kim: ETH Zurich
Rosaria Anna Picca: University of Bari “Aldo Moro”
Bradley J. Nelson: ETH Zurich
Eliseo Ruiz: University of Barcelona (UB)
Salvador Pané: ETH Zurich
Ismael Díez-Pérez: Faculty of Natural, Mathematical & Engineering Sciences, King’s College London
Josep Puigmartí-Luis: University of Barcelona (UB)

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract Electric fields have been highlighted as a smart reagent in nature’s enzymatic machinery, as they can directly trigger or accelerate chemical processes with stereo- and regio-specificity. In enzymatic catalysis, controlled mass transport of chemical species is also key in facilitating the availability of reactants in the active reaction site. However, recent progress in developing a clean catalysis that profits from oriented electric fields is limited to theoretical and experimental studies at the single molecule level, where both the control over mass transport and scalability cannot be tested. Here, we quantify the electrostatic catalysis of a prototypical Huisgen cycloaddition in a large-area electrode surface and directly compare its performance to the conventional Cu(I) catalysis. Our custom-built microfluidic cell enhances reagent transport towards the electrified reactive interface. This continuous-flow microfluidic electrostatic reactor is an example of an electric-field driven platform where clean large-scale electrostatic catalytic processes can be efficiently implemented and regulated.

Date: 2024
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DOI: 10.1038/s41467-024-44716-2

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