Self-propelled assembly of nanoparticles with self-catalytic regulation for tumour-specific imaging and therapy

Mengmeng Xia, Qiyue Wang, Yamin Liu, Chunyan Fang, Bo Zhang, Shengfei Yang, Fu Zhou, Peihua Lin, Mingzheng Gu, Canyu Huang, Xiaojun Zhang, Fangyuan Li (), Hongying Liu (), Guangfeng Wang () and Daishun Ling ()
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Mengmeng Xia: Anhui Normal University
Qiyue Wang: Shanghai Jiao Tong University
Yamin Liu: Shanghai Jiao Tong University
Chunyan Fang: Shanghai Jiao Tong University
Bo Zhang: Shanghai Jiao Tong University
Shengfei Yang: Zhejiang University
Fu Zhou: Anhui Normal University
Peihua Lin: Shanghai Jiao Tong University
Mingzheng Gu: Anhui Normal University
Canyu Huang: Shanghai Jiao Tong University
Xiaojun Zhang: Anhui Normal University
Fangyuan Li: Zhejiang University
Hongying Liu: Hangzhou Dianzi University
Guangfeng Wang: Anhui Normal University
Daishun Ling: Shanghai Jiao Tong University

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Targeted assembly of nanoparticles in biological systems holds great promise for disease-specific imaging and therapy. However, the current manipulation of nanoparticle dynamics is primarily limited to organic pericyclic reactions, which necessitate the introduction of synthetic functional groups as bioorthogonal handles on the nanoparticles, leading to complex and laborious design processes. Here, we report the synthesis of tyrosine (Tyr)-modified peptides-capped iodine (I) doped CuS nanoparticles (CuS-I@P1 NPs) as self-catalytic building blocks that undergo self-propelled assembly inside tumour cells via Tyr-Tyr condensation reactions catalyzed by the nanoparticles themselves. Upon cellular internalization, the CuS-I@P1 NPs undergo furin-guided condensation reactions, leading to the formation of CuS-I nanoparticle assemblies through dityrosine bond. The tumour-specific furin-instructed intracellular assembly of CuS-I NPs exhibits activatable dual-modal imaging capability and enhanced photothermal effect, enabling highly efficient imaging and therapy of tumours. The robust nanoparticle self-catalysis-regulated in situ assembly, facilitated by natural handles, offers the advantages of convenient fabrication, high reaction specificity, and biocompatibility, representing a generalizable strategy for target-specific activatable biomedical imaging and therapy.

Date: 2024
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DOI: 10.1038/s41467-024-44736-y

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