Wheat Pm55 alleles exhibit distinct interactions with an inhibitor to cause different powdery mildew resistance

Chuntian Lu, Jie Du, Heyu Chen, Shuangjun Gong, Yinyu Jin, Xiangru Meng, Ting Zhang, Bisheng Fu, István Molnár, Kateřina Holušová, Mahmoud Said, Liping Xing, Lingna Kong, Jaroslav Doležel, Genying Li, Jizhong Wu, Peidu Chen, Aizhong Cao and Ruiqi Zhang ()
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Chuntian Lu: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Jie Du: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Heyu Chen: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Shuangjun Gong: Hubei Academy of Agricultural Sciences
Yinyu Jin: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Xiangru Meng: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Ting Zhang: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Bisheng Fu: Zhongshan Biological Breeding Laboratory
István Molnár: Eötvös Loránd Research Network (ELKH)
Kateřina Holušová: Centre of Plant Structural and Functional Genomics
Mahmoud Said: Centre of Plant Structural and Functional Genomics
Liping Xing: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Lingna Kong: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Jaroslav Doležel: Centre of Plant Structural and Functional Genomics
Genying Li: Shandong Academy of Agricultural Sciences
Jizhong Wu: Zhongshan Biological Breeding Laboratory
Peidu Chen: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Aizhong Cao: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP
Ruiqi Zhang: College of Agronomy of Nanjing Agricultural University/State Key Laboratory of Crop Genetics & Germplasm Enhancement and Application /JCIC-MCP

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Powdery mildew poses a significant threat to wheat crops worldwide, emphasizing the need for durable disease control strategies. The wheat-Dasypyrum villosum T5AL·5 V#4 S and T5DL·5 V#4 S translocation lines carrying powdery mildew resistant gene Pm55 shows developmental-stage and tissue-specific resistance, whereas T5DL·5 V#5 S line carrying Pm5V confers resistance at all stages. Here, we clone Pm55 and Pm5V, and reveal that they are allelic and renamed as Pm55a and Pm55b, respectively. The two Pm55 alleles encode coiled-coil, nucleotide-binding site-leucine-rich repeat (CNL) proteins, conferring broad-spectrum resistance to powdery mildew. However, they interact differently with a linked inhibitor gene, SuPm55 to cause different resistance to wheat powdery mildew. Notably, Pm55 and SuPm55 encode unrelated CNL proteins, and the inactivation of SuPm55 significantly reduces plant fitness. Combining SuPm55/Pm55a and Pm55b in wheat does not result in allele suppression or yield penalty. Our results provide not only insights into the suppression of resistance in wheat, but also a strategy for breeding durable resistance.

Date: 2024
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DOI: 10.1038/s41467-024-44796-0

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