Altered DNA methylation within DNMT3A, AHRR, LTA/TNF loci mediates the effect of smoking on inflammatory bowel disease

Han Zhang, Rahul Kalla, Jie Chen, Jianhui Zhao, Xuan Zhou, Alex Adams, Alexandra Noble, Nicholas T. Ventham, Judith Wellens, Gwo-Tzer Ho, Malcolm G. Dunlop, Jan Krzysztof Nowak, Yuan Ding, Zhanju Liu (), Jack Satsangi (), Evropi Theodoratou () and Xue Li ()
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Han Zhang: Zhejiang University School of Medicine
Rahul Kalla: University of Edinburgh
Jie Chen: Zhejiang University School of Medicine
Jianhui Zhao: Zhejiang University School of Medicine
Xuan Zhou: Zhejiang University School of Medicine
Alex Adams: University of Oxford, John Radcliffe Hospital
Alexandra Noble: University of Oxford, John Radcliffe Hospital
Nicholas T. Ventham: University of Edinburgh, Western General Hospital
Judith Wellens: University of Oxford, John Radcliffe Hospital
Gwo-Tzer Ho: University of Edinburgh
Malcolm G. Dunlop: University of Edinburgh
Jan Krzysztof Nowak: Poznan University of Medical Sciences
Yuan Ding: Zhejiang University School of Medicine
Zhanju Liu: Tongji University School of Medicine
Jack Satsangi: University of Oxford, John Radcliffe Hospital
Evropi Theodoratou: University of Edinburgh
Xue Li: Zhejiang University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract This work aims to investigate how smoking exerts effect on the development of inflammatory bowel disease (IBD). A prospective cohort study and a Mendelian randomization study are first conducted to evaluate the association between smoking behaviors, smoking-related DNA methylation and the risks of Crohn’s disease (CD) and ulcerative colitis (UC). We then perform both genome-wide methylation analysis and co-localization analysis to validate the observed associations. Compared to never smoking, current and previous smoking habits are associated with increased CD (P = 7.09 × 10−10) and UC (P

Date: 2024
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DOI: 10.1038/s41467-024-44841-y

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