Genetic architecture distinguishes tinnitus from hearing loss

Royce E. Clifford (), Adam X. Maihofer, Chris Chatzinakos, Jonathan R. I. Coleman, Nikolaos P. Daskalakis, Marianna Gasperi, Kelleigh Hogan, Elizabeth A. Mikita, Murray B. Stein, Catherine Tcheandjieu, Francesca Telese, Yanning Zuo, Allen F. Ryan and Caroline M. Nievergelt ()
Additional contact information
Royce E. Clifford: Veterans Affairs San Diego Healthcare System, Research Service
Adam X. Maihofer: Veterans Affairs San Diego Healthcare System, Research Service
Chris Chatzinakos: Harvard Medical School, Department of Psychiatry
Jonathan R. I. Coleman: King’s College London, NIHR Maudsley BRC
Nikolaos P. Daskalakis: Harvard Medical School, Department of Psychiatry
Marianna Gasperi: Veterans Affairs San Diego Healthcare System, Research Service
Kelleigh Hogan: Veterans Affairs San Diego Healthcare System, Research Service
Elizabeth A. Mikita: Veterans Affairs San Diego Healthcare System, Research Service
Murray B. Stein: University of California San Diego, Department of Psychiatry
Catherine Tcheandjieu: VA Palo Alto Health Care System
Francesca Telese: University of California San Diego, Department of Psychiatry
Yanning Zuo: University of California San Diego, Department of Psychiatry
Allen F. Ryan: Veterans Affairs San Diego Healthcare System, Research Service
Caroline M. Nievergelt: Veterans Affairs San Diego Healthcare System, Research Service

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Tinnitus is a heritable, highly prevalent auditory disorder treated by multiple medical specialties. Previous GWAS indicated high genetic correlations between tinnitus and hearing loss, with little indication of differentiating signals. We present a GWAS meta-analysis, triple previous sample sizes, and expand to non-European ancestries. GWAS in 596,905 Million Veteran Program subjects identified 39 tinnitus loci, and identified genes related to neuronal synapses and cochlear structural support. Applying state-of-the-art analytic tools, we confirm a large number of shared variants, but also a distinct genetic architecture of tinnitus, with higher polygenicity and large proportion of variants not shared with hearing difficulty. Tissue-expression analysis for tinnitus infers broad enrichment across most brain tissues, in contrast to hearing difficulty. Finally, tinnitus is not only correlated with hearing loss, but also with a spectrum of psychiatric disorders, providing potential new avenues for treatment. This study establishes tinnitus as a distinct disorder separate from hearing difficulties.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-44842-x Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44842-x

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-44842-x

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().