A presynaptic source drives differing levels of surround suppression in two mouse retinal ganglion cell types

David Swygart, Wan-Qing Yu, Shunsuke Takeuchi, Rachel O. L. Wong and Gregory W. Schwartz ()
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David Swygart: Northwestern University Interdepartmental Neuroscience Program
Wan-Qing Yu: University of Washington
Shunsuke Takeuchi: The University of Tokyo
Rachel O. L. Wong: University of Washington
Gregory W. Schwartz: Northwestern University Interdepartmental Neuroscience Program

Nature Communications, 2024, vol. 15, issue 1, 1-20

Abstract: Abstract In early sensory systems, cell-type diversity generally increases from the periphery into the brain, resulting in a greater heterogeneity of responses to the same stimuli. Surround suppression is a canonical visual computation that begins within the retina and is found at varying levels across retinal ganglion cell types. Our results show that heterogeneity in the level of surround suppression occurs subcellularly at bipolar cell synapses. Using single-cell electrophysiology and serial block-face scanning electron microscopy, we show that two retinal ganglion cell types exhibit very different levels of surround suppression even though they receive input from the same bipolar cell types. This divergence of the bipolar cell signal occurs through synapse-specific regulation by amacrine cells at the scale of tens of microns. These findings indicate that each synapse of a single bipolar cell can carry a unique visual signal, expanding the number of possible functional channels at the earliest stages of visual processing.

Date: 2024
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DOI: 10.1038/s41467-024-44851-w

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