Structural connectome architecture shapes the maturation of cortical morphology from childhood to adolescence

Xinyuan Liang, Lianglong Sun, Xuhong Liao, Tianyuan Lei, Mingrui Xia, Dingna Duan, Zilong Zeng, Qiongling Li, Zhilei Xu, Weiwei Men, Yanpei Wang, Shuping Tan, Jia-Hong Gao, Shaozheng Qin, Sha Tao, Qi Dong, Tengda Zhao () and Yong He ()
Additional contact information
Xinyuan Liang: Beijing Normal University
Lianglong Sun: Beijing Normal University
Xuhong Liao: Beijing Normal University
Tianyuan Lei: Beijing Normal University
Mingrui Xia: Beijing Normal University
Dingna Duan: Beijing Normal University
Zilong Zeng: Beijing Normal University
Qiongling Li: Beijing Normal University
Zhilei Xu: Beijing Normal University
Weiwei Men: Peking University
Yanpei Wang: Beijing Normal University
Shuping Tan: Peking University Huilongguan Clinical Medical School
Jia-Hong Gao: Peking University
Shaozheng Qin: Beijing Normal University
Sha Tao: Beijing Normal University
Qi Dong: Beijing Normal University
Tengda Zhao: Beijing Normal University
Yong He: Beijing Normal University

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract Cortical thinning is an important hallmark of the maturation of brain morphology during childhood and adolescence. However, the connectome-based wiring mechanism that underlies cortical maturation remains unclear. Here, we show cortical thinning patterns primarily located in the lateral frontal and parietal heteromodal nodes during childhood and adolescence, which are structurally constrained by white matter network architecture and are particularly represented using a network-based diffusion model. Furthermore, connectome-based constraints are regionally heterogeneous, with the largest constraints residing in frontoparietal nodes, and are associated with gene expression signatures of microstructural neurodevelopmental events. These results are highly reproducible in another independent dataset. These findings advance our understanding of network-level mechanisms and the associated genetic basis that underlies the maturational process of cortical morphology during childhood and adolescence.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-024-44863-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44863-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-44863-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().