Subfield-specific interneuron circuits govern the hippocampal response to novelty in male mice

Thomas Hainmueller (), Aurore Cazala, Li-Wen Huang and Marlene Bartos ()
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Thomas Hainmueller: University of Freiburg, Medical Faculty
Aurore Cazala: University of Freiburg, Medical Faculty
Li-Wen Huang: University of Freiburg, Medical Faculty
Marlene Bartos: University of Freiburg, Medical Faculty

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract The hippocampus is the brain’s center for episodic memories. Its subregions, the dentate gyrus and CA1-3, are differentially involved in memory encoding and recall. Hippocampal principal cells represent episodic features like movement, space, and context, but less is known about GABAergic interneurons. Here, we performed two-photon calcium imaging of parvalbumin- and somatostatin-expressing interneurons in the dentate gyrus and CA1-3 of male mice exploring virtual environments. Parvalbumin-interneurons increased activity with running-speed and reduced it in novel environments. Somatostatin-interneurons in CA1-3 behaved similar to parvalbumin-expressing cells, but their dentate gyrus counterparts increased activity during rest and in novel environments. Congruently, chemogenetic silencing of dentate parvalbumin-interneurons had prominent effects in familiar contexts, while silencing somatostatin-expressing cells increased similarity of granule cell representations between novel and familiar environments. Our data indicate unique roles for parvalbumin- and somatostatin-positive interneurons in the dentate gyrus that are distinct from those in CA1-3 and may support routing of novel information.

Date: 2024
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DOI: 10.1038/s41467-024-44882-3

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