Dual electrical stimulation at spinal-muscular interface reconstructs spinal sensorimotor circuits after spinal cord injury

Kai Zhou, Wei Wei, Dan Yang, Hui Zhang, Wei Yang, Yunpeng Zhang, Yingnan Nie, Mingming Hao, Pengcheng Wang, Hang Ruan, Ting Zhang, Shouyan Wang and Yaobo Liu ()
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Kai Zhou: The Second Affiliated Hospital of Soochow University
Wei Wei: The Second Affiliated Hospital of Soochow University
Dan Yang: The Second Affiliated Hospital of Soochow University
Hui Zhang: The Second Affiliated Hospital of Soochow University
Wei Yang: The Second Affiliated Hospital of Soochow University
Yunpeng Zhang: Chinese Academy of Sciences
Yingnan Nie: Fudan University
Mingming Hao: Chinese Academy of Sciences
Pengcheng Wang: Soochow University
Hang Ruan: Soochow University
Ting Zhang: Chinese Academy of Sciences
Shouyan Wang: Fudan University
Yaobo Liu: The Second Affiliated Hospital of Soochow University

Nature Communications, 2024, vol. 15, issue 1, 1-26

Abstract: Abstract The neural signals produced by varying electrical stimulation parameters lead to characteristic neural circuit responses. However, the characteristics of neural circuits reconstructed by electrical signals remain poorly understood, which greatly limits the application of such electrical neuromodulation techniques for the treatment of spinal cord injury. Here, we develop a dual electrical stimulation system that combines epidural electrical and muscle stimulation to mimic feedforward and feedback electrical signals in spinal sensorimotor circuits. We demonstrate that a stimulus frequency of 10−20 Hz under dual stimulation conditions is required for structural and functional reconstruction of spinal sensorimotor circuits, which not only activates genes associated with axonal regeneration of motoneurons, but also improves the excitability of spinal neurons. Overall, the results provide insights into neural signal decoding during spinal sensorimotor circuit reconstruction, suggesting that the combination of epidural electrical and muscle stimulation is a promising method for the treatment of spinal cord injury.

Date: 2024
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DOI: 10.1038/s41467-024-44898-9

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