A drug-free cardiovascular stent functionalized with tailored collagen supports in-situ healing of vascular tissues

Haoshuang Wu, Li Yang, Rifang Luo, Li Li, Tiantian Zheng, Kaiyang Huang, Yumei Qin, Xia Yang, Xingdong Zhang and Yunbing Wang ()
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Haoshuang Wu: Sichuan University
Li Yang: Sichuan University
Rifang Luo: Sichuan University
Li Li: West China Hospital of Sichuan University
Tiantian Zheng: Sichuan University
Kaiyang Huang: Sichuan University
Yumei Qin: Sichuan University
Xia Yang: Shanxi Jinbo Bio-Pharmaceutical Co., Ltd.
Xingdong Zhang: Sichuan University
Yunbing Wang: Sichuan University

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract Drug-eluting stent implantation suppresses the excessive proliferation of smooth muscle cells to reduce in-stent restenosis. However, the efficacy of drug-eluting stents remains limited due to delayed reendothelialization, impaired intimal remodeling, and potentially increased late restenosis. Here, we show that a drug-free coating formulation functionalized with tailored recombinant humanized type III collagen exerts one-produces-multi effects in response to injured tissue following stent implantation. We demonstrate that the one-produces-multi coating possesses anticoagulation, anti-inflammatory, and intimal hyperplasia suppression properties. We perform transcriptome analysis to indicate that the drug-free coating favors the endothelialization process and induces the conversion of smooth muscle cells to a contractile phenotype. We find that compared to drug-eluting stents, our drug-free stent reduces in-stent restenosis in rabbit and porcine models and improves vascular neointimal healing in a rabbit model. Collectively, the one-produces-multi drug-free system represents a promising strategy for the next-generation of stents.

Date: 2024
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DOI: 10.1038/s41467-024-44902-2

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