A wearable electrostimulation-augmented ionic-gel photothermal patch doped with MXene for skin tumor treatment

Xingkai Ju, Jiao Kong, Guohua Qi (), Shuping Hou, Xingkang Diao, Shaojun Dong and Yongdong Jin ()
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Xingkai Ju: Chinese Academy of Sciences
Jiao Kong: Chinese Academy of Sciences
Guohua Qi: Chinese Academy of Sciences
Shuping Hou: Chinese Academy of Sciences
Xingkang Diao: Chinese Academy of Sciences
Shaojun Dong: Chinese Academy of Sciences
Yongdong Jin: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract A wearable biological patch capable of producing multiple responses to light and electricity without interfering with daily activities is highly desired for skin cancer treatment, but remains a key challenge. Herein, the skin-mountable electrostimulation-augmented photothermal patch (eT-patch) comprising transparent ionic gel with MXene (Ti3C2Tx) doping is developed and applied for the treatment of melanoma under photostimulation at 0.5 W/cm2. The eT-patch designed has superior photothermal and electrical characteristics owing to ionic gels doped with MXene which provides high photothermal conversion efficiency and electrical conductivity as a medium. Simultaneously, the ionic gel-based eT-patch having excellent optical transparency actualizes real-time observation of skin response and melanoma treatment process under photothermal and electrical stimulation (PES) co-therapy. Systematical cellular study on anti-tumor mechanism of the eT-patch under PES treatment revealed that eT-patch under PES treatment can synergically trigger cancer cell apoptosis and pyroptosis, which together lead to the death of melanoma cells. Due to the obvious advantages of relatively safe and less side effects in healthy organs, the developed eT-patch provides a promising cost-effective therapeutic strategy for skin tumors and will open a new avenue for biomedical applications of ionic gels.

Date: 2024
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DOI: 10.1038/s41467-024-45070-z

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