Bioinspired light-driven chloride pump with helical porphyrin channels

Chao Li, Yi Zhai, Heming Jiang, Siqi Li, Pengxiang Liu, Longcheng Gao () and Lei Jiang
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Chao Li: Beihang University
Yi Zhai: Beihang University
Heming Jiang: Shenzhen Bay Laboratory
Siqi Li: Beihang University
Pengxiang Liu: Beihang University
Longcheng Gao: Beihang University
Lei Jiang: Beihang University

Nature Communications, 2024, vol. 15, issue 1, 1-9

Abstract: Abstract Halorhodopsin, a light-driven chloride pump, utilizes photonic energy to drive chloride ions across biological membranes, regulating the ion balance and conveying biological information. In the light-driven chloride pump process, the chloride-binding chromophore (protonated Schiff base) is crucial, able to form the active center by absorbing light and triggering the transport cycle. Inspired by halorhodopsin, we demonstrate an artificial light-driven chloride pump using a helical porphyrin channel array with excellent photoactivity and specific chloride selectivity. The helical porphyrin channels are formed by a porphyrin-core star block copolymer, and the defects along the channels can be effectively repaired by doping a small number of porphyrins. The well-repaired porphyrin channel exhibits the light-driven Cl− migration against a 3-fold concentration gradient, showing the ion pumping behavior. The bio-inspired artificial light-driven chloride pump provides a prospect for designing bioinspired responsive ion channel systems and high-performance optogenetics.

Date: 2024
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DOI: 10.1038/s41467-024-45117-1

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