Two way workable microchanneled hydrogel suture to diagnose, treat and monitor the infarcted heart

Fangchao Xue, Shanlan Zhao, Hao Tian, Haoxiang Qin, Xiaochen Li, Zhao Jian, Jiahui Du, Yanzhao Li, Yanhong Wang, Lin Lin, Chen Liu, Yongning Shang, Lang He, Malcolm Xing () and Wen Zeng ()
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Fangchao Xue: Third Military Medical University
Shanlan Zhao: Third Military Medical University
Hao Tian: Third Military Medical University
Haoxiang Qin: Third Military Medical University
Xiaochen Li: Third Military Medical University
Zhao Jian: Third Military Medical University
Jiahui Du: Third Military Medical University
Yanzhao Li: Third Military Medical University
Yanhong Wang: Third Military Medical University
Lin Lin: Third Military Medical University
Chen Liu: Third Military Medical University
Yongning Shang: Third Military Medical University
Lang He: Third Military Medical University
Malcolm Xing: Department of Mechanical Engineering University of Manitoba
Wen Zeng: Third Military Medical University

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract During myocardial infarction, microcirculation disturbance in the ischemic area can cause necrosis and formation of fibrotic tissue, potentially leading to malignant arrhythmia and myocardial remodeling. Here, we report a microchanneled hydrogel suture for two-way signal communication, pumping drugs on demand, and cardiac repair. After myocardial infarction, our hydrogel suture monitors abnormal electrocardiogram through the mobile device and triggers nitric oxide on demand via the hydrogel sutures’ microchannels, thereby inhibiting inflammation, promoting microvascular remodeling, and improving the left ventricular ejection fraction in rats and minipigs by more than 60% and 50%, respectively. This work proposes a suture for bidirectional communication that acts as a cardio-patch to repair myocardial infarction, that remotely monitors the heart, and can deliver drugs on demand.

Date: 2024
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DOI: 10.1038/s41467-024-45144-y

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