The cryo-EM structure of homotetrameric attachment glycoprotein from langya henipavirus

Yingying Guo (), Songyue Wu, Wenting Li, Haonan Yang, Tianhao Shi, Bin Ju (), Zheng Zhang () and Renhong Yan ()
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Yingying Guo: Key University Laboratory of Metabolism and Health of Guangdong, Institute for Biological Electron Microscopy, Southern University of Science and Technology
Songyue Wu: Shenzhen Third People’s Hospital
Wenting Li: Shenzhen Third People’s Hospital
Haonan Yang: Key University Laboratory of Metabolism and Health of Guangdong, Institute for Biological Electron Microscopy, Southern University of Science and Technology
Tianhao Shi: Key University Laboratory of Metabolism and Health of Guangdong, Institute for Biological Electron Microscopy, Southern University of Science and Technology
Bin Ju: Shenzhen Third People’s Hospital
Zheng Zhang: Shenzhen Third People’s Hospital
Renhong Yan: Key University Laboratory of Metabolism and Health of Guangdong, Institute for Biological Electron Microscopy, Southern University of Science and Technology

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Langya Henipavirus (LayV) infection is an emerging zoonotic disease that has been causing respiratory symptoms in China since 2019. For virus entry, LayV’s genome encodes the fusion protein F and the attachment glycoprotein G. However, the structural and functional information regarding LayV-G remains unclear. In this study, we revealed that LayV-G cannot bind to the receptors found in other HNVs, such as ephrin B2/B3, and it shows different antigenicity from HeV-G and NiV-G. Furthermore, we determined the near full-length structure of LayV-G, which displays a distinct mushroom-shaped configuration, distinguishing it from other attachment glycoproteins of HNV. The stalk and transmembrane regions resemble the stem and root of mushroom and four downward-tilted head domains as mushroom cap potentially interact with the F protein and influence membrane fusion process. Our findings enhance the understanding of emerging HNVs that cause human diseases through zoonotic transmission and provide implication for LayV related vaccine development.

Date: 2024
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DOI: 10.1038/s41467-024-45202-5

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