Tissue-specific profiling of age-dependent miRNAomic changes in Caenorhabditis elegans

Xueqing Wang, Quanlong Jiang, Hongdao Zhang, Zhidong He, Yuanyuan Song, Yifan Chen, Na Tang, Yifei Zhou, Yiping Li, Adam Antebi, Ligang Wu (), Jing-Dong J. Han () and Yidong Shen ()
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Xueqing Wang: Chinese Academy of Sciences
Quanlong Jiang: Chinese Academy of Sciences
Hongdao Zhang: Chinese Academy of Sciences
Zhidong He: Chinese Academy of Sciences
Yuanyuan Song: Chinese Academy of Sciences
Yifan Chen: Chinese Academy of Sciences
Na Tang: Chinese Academy of Sciences
Yifei Zhou: Chinese Academy of Sciences
Yiping Li: Chinese Academy of Sciences
Adam Antebi: Max Planck Institute for Biology of Ageing
Ligang Wu: Chinese Academy of Sciences
Jing-Dong J. Han: Peking University
Yidong Shen: Chinese Academy of Sciences

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Ageing exhibits common and distinct features in various tissues, making it critical to decipher the tissue-specific ageing mechanisms. MiRNAs are essential regulators in ageing and are recently highlighted as a class of intercellular messengers. However, little is known about the tissue-specific transcriptomic changes of miRNAs during ageing. C. elegans is a well-established model organism in ageing research. Here, we profile the age-dependent miRNAomic changes in five isolated worm tissues. Besides the diverse ageing-regulated miRNA expression across tissues, we discover numerous miRNAs in the tissues without their transcription. We further profile miRNAs in the extracellular vesicles and find that worm miRNAs undergo inter-tissue trafficking via these vesicles in an age-dependent manner. Using these datasets, we uncover the interaction between body wall muscle-derived mir-1 and DAF-16/FOXO in the intestine, suggesting mir-1 as a messenger in inter-tissue signalling. Taken together, we systematically investigate worm miRNAs in the somatic tissues and extracellular vesicles during ageing, providing a valuable resource to study tissue-autonomous and nonautonomous functions of miRNAs in ageing.

Date: 2024
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DOI: 10.1038/s41467-024-45249-4

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