BCL7A and BCL7B potentiate SWI/SNF-complex-mediated chromatin accessibility to regulate gene expression and vegetative phase transition in plants

Yawen Lei, Yaoguang Yu, Wei Fu, Tao Zhu, Caihong Wu, Zhihao Zhang, Zewang Yu, Xin Song, Jianqu Xu, Zhenwei Liang, Peitao Lü and Chenlong Li ()
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Yawen Lei: Sun Yat-sen University
Yaoguang Yu: Sun Yat-sen University
Wei Fu: Sun Yat-sen University
Tao Zhu: Sun Yat-sen University
Caihong Wu: Sun Yat-sen University
Zhihao Zhang: Sun Yat-sen University
Zewang Yu: Sun Yat-sen University
Xin Song: Sun Yat-sen University
Jianqu Xu: Sun Yat-sen University
Zhenwei Liang: Sun Yat-sen University
Peitao Lü: Fujian Agriculture and Forestry University
Chenlong Li: Sun Yat-sen University

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract Switch defective/sucrose non-fermentable (SWI/SNF) chromatin remodeling complexes are multi-subunit machineries that establish and maintain chromatin accessibility and gene expression by regulating chromatin structure. However, how the remodeling activities of SWI/SNF complexes are regulated in eukaryotes remains elusive. B-cell lymphoma/leukemia protein 7 A/B/C (BCL7A/B/C) have been reported as subunits of SWI/SNF complexes for decades in animals and recently in plants; however, the role of BCL7 subunits in SWI/SNF function remains undefined. Here, we identify a unique role for plant BCL7A and BCL7B homologous subunits in potentiating the genome-wide chromatin remodeling activities of SWI/SNF complexes in plants. BCL7A/B require the catalytic ATPase BRAHMA (BRM) to assemble with the signature subunits of the BRM-Associated SWI/SNF complexes (BAS) and for genomic binding at a subset of target genes. Loss of BCL7A and BCL7B diminishes BAS-mediated genome-wide chromatin accessibility without changing the stability and genomic targeting of the BAS complex, highlighting the specialized role of BCL7A/B in regulating remodeling activity. We further show that BCL7A/B fine-tune the remodeling activity of BAS complexes to generate accessible chromatin at the juvenility resetting region (JRR) of the microRNAs MIR156A/C for plant juvenile identity maintenance. In summary, our work uncovers the function of previously elusive SWI/SNF subunits in multicellular eukaryotes and provides insights into the mechanisms whereby plants memorize the juvenile identity through SWI/SNF-mediated control of chromatin accessibility.

Date: 2024
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DOI: 10.1038/s41467-024-45250-x

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