Tuning oxidant and antioxidant activities of ceria by anchoring copper single-site for antibacterial application

Peng Jiang, Ludan Zhang, Xiaolong Liu, Chenliang Ye, Peng Zhu, Ting Tan (), Dingsheng Wang () and Yuguang Wang ()
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Peng Jiang: Tsinghua University
Ludan Zhang: Peking University School and Hospital of Stomatology
Xiaolong Liu: Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences
Chenliang Ye: Tsinghua University
Peng Zhu: Tsinghua University
Ting Tan: Laboratory of Theoretical and Computational Nanoscience, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences
Dingsheng Wang: Tsinghua University
Yuguang Wang: Peking University School and Hospital of Stomatology

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract The reaction system of hydrogen peroxide (H2O2) catalyzed by nanozyme has a broad prospect in antibacterial treatment. However, the complex catalytic activities of nanozymes lead to multiple pathways reacting in parallel, causing uncertain antibacterial results. New approach to effectively regulate the multiple catalytic activities of nanozyme is in urgent need. Herein, Cu single site is modified on nanoceria with various catalytic activities, such as peroxidase-like activity (POD) and hydroxyl radical antioxidant capacity (HORAC). Benefiting from the interaction between coordinated Cu and CeO2 substrate, POD is enhanced while HORAC is inhibited, which is further confirmed by density functional theory (DFT) calculations. Cu-CeO2 + H2O2 system shows good antibacterial properties both in vitro and in vivo. In this work, the strategy based on the interaction between coordinated metal and carrier provides a general clue for optimizing the complex activities of nanozymes.

Date: 2024
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DOI: 10.1038/s41467-024-45255-6

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