Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Sanzhima Garmaeva, Trishla Sinha, Anastasia Gulyaeva, Nataliia Kuzub, Johanne E. Spreckels, Sergio Andreu-Sánchez, Ranko Gacesa, Arnau Vich Vila, Siobhan Brushett, Marloes Kruk, Jackie Dekens, Jan Sikkema, Folkert Kuipers, Andrey N. Shkoporov, Colin Hill, Sicco Scherjon, Cisca Wijmenga, Jingyuan Fu, Alexander Kurilshikov and Alexandra Zhernakova ()
Additional contact information
Sanzhima Garmaeva: University of Groningen, University Medical Center Groningen
Trishla Sinha: University of Groningen, University Medical Center Groningen
Anastasia Gulyaeva: University of Groningen, University Medical Center Groningen
Nataliia Kuzub: University of Groningen, University Medical Center Groningen
Johanne E. Spreckels: University of Groningen, University Medical Center Groningen
Sergio Andreu-Sánchez: University of Groningen, University Medical Center Groningen
Ranko Gacesa: University of Groningen, University Medical Center Groningen
Arnau Vich Vila: University of Groningen, University Medical Center Groningen
Siobhan Brushett: University of Groningen, University Medical Center Groningen
Marloes Kruk: University of Groningen, University Medical Center Groningen
Jackie Dekens: University of Groningen, University Medical Center Groningen
Jan Sikkema: University Medical Center Groningen, Center for Development and Innovation
Folkert Kuipers: University of Groningen, University Medical Center Groningen
Andrey N. Shkoporov: APC Microbiome Ireland, University College Cork
Colin Hill: APC Microbiome Ireland, University College Cork
Sicco Scherjon: University of Groningen, University Medical Center Groningen
Cisca Wijmenga: University of Groningen, University Medical Center Groningen
Jingyuan Fu: University of Groningen, University Medical Center Groningen
Alexander Kurilshikov: University of Groningen, University Medical Center Groningen
Alexandra Zhernakova: University of Groningen, University Medical Center Groningen

Nature Communications, 2024, vol. 15, issue 1, 1-19

Abstract: Abstract Early development of the gut ecosystem is crucial for lifelong health. While infant gut bacterial communities have been studied extensively, the infant gut virome remains under-explored. To study the development of the infant gut virome over time and the factors that shape it, we longitudinally assess the composition of gut viruses and their bacterial hosts in 30 women during and after pregnancy and in their 32 infants during their first year of life. Using shotgun metagenomic sequencing applied to dsDNA extracted from Virus-Like Particles (VLPs) and bacteria, we generate 205 VLP metaviromes and 322 total metagenomes. With this data, we show that while the maternal gut virome composition remains stable during late pregnancy and after birth, the infant gut virome is dynamic in the first year of life. Notably, infant gut viromes contain a higher abundance of active temperate phages compared to maternal gut viromes, which decreases over the first year of life. Moreover, we show that the feeding mode and place of delivery influence the gut virome composition of infants. Lastly, we provide evidence of co-transmission of viral and bacterial strains from mothers to infants, demonstrating that infants acquire some of their virome from their mother’s gut.

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45257-4

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DOI: 10.1038/s41467-024-45257-4

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