Fasting-mimicking diet causes hepatic and blood markers changes indicating reduced biological age and disease risk

Sebastian Brandhorst, Morgan E. Levine, Min Wei, Mahshid Shelehchi, Todd E. Morgan, Krishna S. Nayak, Tanya Dorff, Kurt Hong, Eileen M. Crimmins, Pinchas Cohen and Valter D. Longo ()
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Sebastian Brandhorst: University of Southern California
Morgan E. Levine: Yale School of Medicine
Min Wei: University of Southern California
Mahshid Shelehchi: University of Southern California
Todd E. Morgan: University of Southern California
Krishna S. Nayak: Viterbi School of Engineering, University of Southern California
Tanya Dorff: Keck School of Medicine, University of Southern California
Kurt Hong: Keck School of Medicine of USC
Eileen M. Crimmins: University of Southern California
Pinchas Cohen: University of Southern California
Valter D. Longo: University of Southern California

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract In mice, periodic cycles of a fasting mimicking diet (FMD) protect normal cells while killing damaged cells including cancer and autoimmune cells, reduce inflammation, promote multi-system regeneration, and extend longevity. Here, we performed secondary and exploratory analysis of blood samples from a randomized clinical trial (NCT02158897) and show that 3 FMD cycles in adult study participants are associated with reduced insulin resistance and other pre-diabetes markers, lower hepatic fat (as determined by magnetic resonance imaging) and increased lymphoid to myeloid ratio: an indicator of immune system age. Based on a validated measure of biological age predictive of morbidity and mortality, 3 FMD cycles were associated with a decrease of 2.5 years in median biological age, independent of weight loss. Nearly identical findings resulted from a second clinical study (NCT04150159). Together these results provide initial support for beneficial effects of the FMD on multiple cardiometabolic risk factors and biomarkers of biological age.

Date: 2024
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DOI: 10.1038/s41467-024-45260-9

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