Diffusible fraction of niche BMP ligand safeguards stem-cell differentiation

Sharif M. Ridwan, Autumn Twillie, Samaneh Poursaeid, Emma Kristine Beard, Muhammed Burak Bener, Matthew Antel, Ann E. Cowan, Shinya Matsuda () and Mayu Inaba ()
Additional contact information
Sharif M. Ridwan: University of Connecticut Health Center
Autumn Twillie: University of Connecticut Health Center
Samaneh Poursaeid: University of Connecticut Health Center
Emma Kristine Beard: University of Connecticut Health Center
Muhammed Burak Bener: University of Connecticut Health Center
Matthew Antel: University of Connecticut Health Center
Ann E. Cowan: University of Connecticut Health Center
Shinya Matsuda: Biozentrum, University of Basel
Mayu Inaba: University of Connecticut Health Center

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Drosophila male germline stem cells (GSCs) reside at the tip of the testis and surround a cluster of niche cells. Decapentaplegic (Dpp) is one of the well-established ligands and has a major role in maintaining stem cells located in close proximity. However, the existence and the role of the diffusible fraction of Dpp outside of the niche have been unclear. Here, using genetically-encoded nanobodies called Morphotraps, we physically block Dpp diffusion without interfering with niche-stem cell signaling and find that a diffusible fraction of Dpp is required to ensure differentiation of GSC daughter cells, opposite of its role in maintenance of GSC in the niche. Our work provides an example in which a soluble niche ligand induces opposed cellular responses in stem cells versus in differentiating descendants to ensure spatial control of the niche. This may be a common mechanism to regulate tissue homeostasis.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-45408-7 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45408-7

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-45408-7

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().