Mechanistic characterization of a Drosophila model of paraneoplastic nephrotic syndrome

Jun Xu (), Ying Liu (), Fangying Yang, Yurou Cao, Weihang Chen, Joshua Shing Shun Li, Shuai Zhang, Aram Comjean, Yanhui Hu and Norbert Perrimon ()
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Jun Xu: Chinese Academy of Sciences
Ying Liu: Blavatnik Institute, Harvard Medical School
Fangying Yang: Chinese Academy of Sciences
Yurou Cao: Chinese Academy of Sciences
Weihang Chen: Blavatnik Institute, Harvard Medical School
Joshua Shing Shun Li: Blavatnik Institute, Harvard Medical School
Shuai Zhang: Chinese Academy of Sciences
Aram Comjean: Blavatnik Institute, Harvard Medical School
Yanhui Hu: Blavatnik Institute, Harvard Medical School
Norbert Perrimon: Blavatnik Institute, Harvard Medical School

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Paraneoplastic syndromes occur in cancer patients and originate from dysfunction of organs at a distance from the tumor or its metastasis. A wide range of organs can be affected in paraneoplastic syndromes; however, the pathological mechanisms by which tumors influence host organs are poorly understood. Recent studies in the fly uncovered that tumor secreted factors target host organs, leading to pathological effects. In this study, using a Drosophila gut tumor model, we characterize a mechanism of tumor-induced kidney dysfunction. Specifically, we find that Pvf1, a PDGF/VEGF signaling ligand, secreted by gut tumors activates the PvR/JNK/Jra signaling pathway in the principal cells of the kidney, leading to mis-expression of renal genes and paraneoplastic renal syndrome-like phenotypes. Our study describes an important mechanism by which gut tumors perturb the function of the kidney, which might be of clinical relevance for the treatment of paraneoplastic syndromes.

Date: 2024
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DOI: 10.1038/s41467-024-45493-8

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