Malnutrition enteropathy in Zambian and Zimbabwean children with severe acute malnutrition: A multi-arm randomized phase II trial

Kanta Chandwe, Mutsa Bwakura-Dangarembizi, Beatrice Amadi, Gertrude Tawodzera, Deophine Ngosa, Anesu Dzikiti, Nivea Chulu, Robert Makuyana, Kanekwa Zyambo, Kuda Mutasa, Chola Mulenga, Ellen Besa, Jonathan P. Sturgeon, Shepherd Mudzingwa, Bwalya Simunyola, Lydia Kazhila, Masuzyo Zyambo, Hazel Sonkwe, Batsirai Mutasa, Miyoba Chipunza, Virginia Sauramba, Lisa Langhaug, Victor Mudenda, Simon H. Murch, Susan Hill, Raymond J. Playford, Kelley VanBuskirk, Andrew J. Prendergast and Paul Kelly ()
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Kanta Chandwe: University of Zambia School of Medicine
Mutsa Bwakura-Dangarembizi: Zvitambo Institute for Maternal and Child Health Research
Beatrice Amadi: University of Zambia School of Medicine
Gertrude Tawodzera: Zvitambo Institute for Maternal and Child Health Research
Deophine Ngosa: University of Zambia School of Medicine
Anesu Dzikiti: Zvitambo Institute for Maternal and Child Health Research
Nivea Chulu: University of Zambia School of Medicine
Robert Makuyana: Zvitambo Institute for Maternal and Child Health Research
Kanekwa Zyambo: University of Zambia School of Medicine
Kuda Mutasa: Zvitambo Institute for Maternal and Child Health Research
Chola Mulenga: University of Zambia School of Medicine
Ellen Besa: University of Zambia School of Medicine
Jonathan P. Sturgeon: Zvitambo Institute for Maternal and Child Health Research
Shepherd Mudzingwa: Zvitambo Institute for Maternal and Child Health Research
Bwalya Simunyola: University of Zambia School of Medicine
Lydia Kazhila: University of Zambia School of Medicine
Masuzyo Zyambo: University of Zambia School of Medicine
Hazel Sonkwe: University of Zambia School of Medicine
Batsirai Mutasa: Zvitambo Institute for Maternal and Child Health Research
Miyoba Chipunza: University of Zambia School of Medicine
Virginia Sauramba: Zvitambo Institute for Maternal and Child Health Research
Lisa Langhaug: Zvitambo Institute for Maternal and Child Health Research
Victor Mudenda: University of Zambia School of Medicine
Simon H. Murch: Warwick University Medical School
Susan Hill: Great Ormond Street Hospital
Raymond J. Playford: University of West London
Kelley VanBuskirk: University of Zambia School of Medicine
Andrew J. Prendergast: Zvitambo Institute for Maternal and Child Health Research
Paul Kelly: University of Zambia School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract Malnutrition underlies almost half of all child deaths globally. Severe Acute Malnutrition (SAM) carries unacceptable mortality, particularly if accompanied by infection or medical complications, including enteropathy. We evaluated four interventions for malnutrition enteropathy in a multi-centre phase II multi-arm trial in Zambia and Zimbabwe and completed in 2021. The purpose of this trial was to identify therapies which could be taken forward into phase III trials. Children of either sex were eligible for inclusion if aged 6–59 months and hospitalised with SAM (using WHO definitions: WLZ

Date: 2024
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Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45528-0

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DOI: 10.1038/s41467-024-45528-0

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