Nanopore analysis of salvianolic acids in herbal medicines

Pingping Fan, Shanyu Zhang, Yuqin Wang, Tian Li, Hanhan Zhang, Panke Zhang and Shuo Huang ()
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Pingping Fan: Nanjing University
Shanyu Zhang: Nanjing University
Yuqin Wang: Nanjing University
Tian Li: Nanjing University
Hanhan Zhang: Nanjing University
Panke Zhang: Nanjing University
Shuo Huang: Nanjing University

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract Natural herbs, which contain pharmacologically active compounds, have been used historically as medicines. Conventionally, the analysis of chemical components in herbal medicines requires time-consuming sample separation and state-of-the-art analytical instruments. Nanopore, a versatile single molecule sensor, might be suitable to identify bioactive compounds in natural herbs. Here, a phenylboronic acid appended Mycobacterium smegmatis porin A (MspA) nanopore is used as a sensor for herbal medicines. A variety of bioactive compounds based on salvianolic acids, including caffeic acid, protocatechuic acid, protocatechualdehyde, salvianic acid A, rosmarinic acid, lithospermic acid, salvianolic acid A and salvianolic acid B are identified. Using a custom machine learning algorithm, analyte identification is performed with an accuracy of 99.0%. This sensing principle is further used with natural herbs such as Salvia miltiorrhiza, Rosemary and Prunella vulgaris. No complex sample separation or purification is required and the sensing device is highly portable.

Date: 2024
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DOI: 10.1038/s41467-024-45543-1

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