Neuromorphic electro-stimulation based on atomically thin semiconductor for damage-free inflammation inhibition

Rong Bao, Shuiyuan Wang (), Xiaoxian Liu, Kejun Tu, Jingquan Liu, Xiaohe Huang, Chunsen Liu, Peng Zhou () and Shen Liu ()
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Rong Bao: Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shuiyuan Wang: Fudan University
Xiaoxian Liu: Fudan University
Kejun Tu: Shanghai Jiao Tong university
Jingquan Liu: Shanghai Jiao Tong university
Xiaohe Huang: Fudan University
Chunsen Liu: Fudan University
Peng Zhou: Fudan University
Shen Liu: Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

Nature Communications, 2024, vol. 15, issue 1, 1-13

Abstract: Abstract Inflammation, caused by accumulation of inflammatory cytokines from immunocytes, is prevalent in a variety of diseases. Electro-stimulation emerges as a promising candidate for inflammatory inhibition. Although electroacupuncture is free from surgical injury, it faces the challenges of imprecise pathways/current spikes, and insufficiently defined mechanisms, while non-optimal pathway or spike would require high current amplitude, which makes electro-stimulation usually accompanied by damage and complications. Here, we propose a neuromorphic electro-stimulation based on atomically thin semiconductor floating-gate memory interdigital circuit. Direct stimulation is achieved by wrapping sympathetic chain with flexible electrodes and floating-gate memory are programmable to fire bionic spikes, thus minimizing nerve damage. A substantial decrease (73.5%) in inflammatory cytokine IL-6 occurred, which also enabled better efficacy than commercial stimulator at record-low currents with damage-free to sympathetic neurons. Additionally, using transgenic mice, the anti-inflammation effect is determined by β2 adrenergic signaling from myeloid cell lineage (monocytes/macrophages and granulocytes).

Date: 2024
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DOI: 10.1038/s41467-024-45590-8

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