A hepatic network of dendritic cells mediates CD4 T cell help outside lymphoid organs

Kieran English, Rain Kwan, Lauren E. Holz, Claire McGuffog, Jelte M. M. Krol, Daryan Kempe, Tsuneyasu Kaisho, William R. Heath, Leszek Lisowski, Maté Biro, Geoffrey W. McCaughan, David G. Bowen () and Patrick Bertolino ()
Additional contact information
Kieran English: Royal Prince Alfred Hospital
Rain Kwan: Royal Prince Alfred Hospital
Lauren E. Holz: University of Melbourne
Claire McGuffog: Royal Prince Alfred Hospital
Jelte M. M. Krol: Royal Prince Alfred Hospital
Daryan Kempe: University of New South Wales
Tsuneyasu Kaisho: Wakayama Medical University
William R. Heath: University of Melbourne
Leszek Lisowski: The University of Sydney
Maté Biro: University of New South Wales
Geoffrey W. McCaughan: Royal Prince Alfred Hospital
David G. Bowen: Royal Prince Alfred Hospital
Patrick Bertolino: Royal Prince Alfred Hospital

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract While CD4+ T cells are a prerequisite for CD8+ T cell-mediated protection against intracellular hepatotropic pathogens, the mechanisms facilitating the transfer of CD4-help to intrahepatic CD8+ T cells are unknown. Here, we developed an experimental system to investigate cognate CD4+ and CD8+ T cell responses to a model-antigen expressed de novo in hepatocytes and reveal that after initial priming, effector CD4+ and CD8+ T cells migrate into portal tracts and peri-central vein regions of the liver where they cluster with type-1 conventional dendritic cells. These dendritic cells are locally licensed by CD4+ T cells and expand the number of CD8+ T cells in situ, resulting in larger effector and memory CD8+ T cell pools. These findings reveal that CD4+ T cells promote intrahepatic immunity by amplifying the CD8+ T cell response via peripheral licensing of hepatic type-1 conventional dendritic cells and identify intrahepatic perivascular compartments specialized in facilitating effector T cell-dendritic cell interactions.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-45612-5 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45612-5

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-45612-5

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().