Ultrasound-activated piezo-hot carriers trigger tandem catalysis coordinating cuproptosis-like bacterial death against implant infections

Yanli Huang, Xufeng Wan, Qiang Su, Chunlin Zhao, Jian Cao, Yan Yue, Shuoyuan Li, Xiaoting Chen, Jie Yin, Yi Deng, Xianzeng Zhang (), Tianmin Wu (), Zongke Zhou () and Duan Wang ()
Additional contact information
Yanli Huang: Fujian Normal University
Xufeng Wan: Sichuan University
Qiang Su: The Third Hospital of Mianyang, Sichuan Mental Health Center
Chunlin Zhao: Fuzhou University
Jian Cao: Sichuan University
Yan Yue: Sichuan University
Shuoyuan Li: Sichuan University
Xiaoting Chen: Sichuan University
Jie Yin: Institute of Materials Research and Engineering, Agency for Science, Technology and Research
Yi Deng: Sichuan University
Xianzeng Zhang: Fujian Normal University
Tianmin Wu: Fujian Normal University
Zongke Zhou: Sichuan University
Duan Wang: Sichuan University

Nature Communications, 2024, vol. 15, issue 1, 1-17

Abstract: Abstract Implant-associated infections due to the formation of bacterial biofilms pose a serious threat in medical healthcare, which needs effective therapeutic methods. Here, we propose a multifunctional nanoreactor by spatiotemporal ultrasound-driven tandem catalysis to amplify the efficacy of sonodynamic and chemodynamic therapy. By combining piezoelectric barium titanate with polydopamine and copper, the ultrasound-activated piezo-hot carriers transfer easily to copper by polydopamine. It boosts reactive oxygen species production by piezoelectrics, and facilitates the interconversion between Cu2+ and Cu+ to promote hydroxyl radical generation via Cu+ -catalyzed chemodynamic reactions. Finally, the elevated reactive oxygen species cause bacterial membrane structure loosening and DNA damage. Transcriptomics and metabolomics analysis reveal that intracellular copper overload restricts the tricarboxylic acid cycle, promoting bacterial cuproptosis-like death. Therefore, the polyetherketoneketone scaffold engineered with the designed nanoreactor shows excellent antibacterial performance with ultrasound stimulation and promotes angiogenesis and osteogenesis on-demand in vivo.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.nature.com/articles/s41467-024-45619-y Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45619-y

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-45619-y

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().