Fully bioresorbable hybrid opto-electronic neural implant system for simultaneous electrophysiological recording and optogenetic stimulation

Myeongki Cho, Jeong-Kyu Han, Jungmin Suh, Jeong Jin Kim, Jae Ryun Ryu, In Sik Min, Mingyu Sang, Selin Lim, Tae Soo Kim, Kyubeen Kim, Kyowon Kang, Kyuhyun Hwang, Kanghwan Kim, Eun-Bin Hong, Min-Ho Nam, Jongbaeg Kim, Young Min Song, Gil Ju Lee (), Il-Joo Cho () and Ki Jun Yu ()
Additional contact information
Myeongki Cho: Yonsei University
Jeong-Kyu Han: Korea Institute of Science and Technology
Jungmin Suh: Yonsei University
Jeong Jin Kim: Pusan National University
Jae Ryun Ryu: Korea University
In Sik Min: Yonsei University
Mingyu Sang: Yonsei University
Selin Lim: Yonsei University
Tae Soo Kim: Yonsei University
Kyubeen Kim: Yonsei University
Kyowon Kang: Yonsei University
Kyuhyun Hwang: Yonsei University
Kanghwan Kim: Korea Institute of Science and Technology
Eun-Bin Hong: Korea Institute of Science and Technology 5
Min-Ho Nam: Korea Institute of Science and Technology 5
Jongbaeg Kim: Yonsei University
Young Min Song: Gwangju Institute of Science and Technology (GIST)
Gil Ju Lee: Pusan National University
Il-Joo Cho: Korea University
Ki Jun Yu: Yonsei University

Nature Communications, 2024, vol. 15, issue 1, 1-16

Abstract: Abstract Bioresorbable neural implants based on emerging classes of biodegradable materials offer a promising solution to the challenges of secondary surgeries for removal of implanted devices required for existing neural implants. In this study, we introduce a fully bioresorbable flexible hybrid opto-electronic system for simultaneous electrophysiological recording and optogenetic stimulation. The flexible and soft device, composed of biodegradable materials, has a direct optical and electrical interface with the curved cerebral cortex surface while exhibiting excellent biocompatibility. Optimized to minimize light transmission losses and photoelectric artifact interference, the device was chronically implanted in the brain of transgenic mice and performed to photo-stimulate the somatosensory area while recording local field potentials. Thus, the presented hybrid neural implant system, comprising biodegradable materials, promises to provide monitoring and therapy modalities for versatile applications in biomedicine.

Date: 2024
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DOI: 10.1038/s41467-024-45803-0

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