JAK-STAT-dependent contact between follicle cells and the oocyte controls Drosophila anterior-posterior polarity and germline development

Charlotte Mallart, Sophie Netter, Fabienne Chalvet, Sandra Claret, Antoine Guichet, Jacques Montagne, Anne-Marie Pret and Marianne Malartre ()
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Charlotte Mallart: Université Paris-Saclay
Sophie Netter: Université Paris-Saclay
Fabienne Chalvet: Université Paris-Saclay
Sandra Claret: Institut Jacques Monod
Antoine Guichet: Institut Jacques Monod
Jacques Montagne: Université Paris-Saclay
Anne-Marie Pret: Université Paris-Saclay
Marianne Malartre: Université Paris-Saclay

Nature Communications, 2024, vol. 15, issue 1, 1-18

Abstract: Abstract The number of embryonic primordial germ cells in Drosophila is determined by the quantity of germ plasm, whose assembly starts in the posterior region of the oocyte during oogenesis. Here, we report that extending JAK-STAT activity in the posterior somatic follicular epithelium leads to an excess of primordial germ cells in the future embryo. We show that JAK-STAT signaling is necessary for the differentiation of approximately 20 specialized follicle cells maintaining tight contact with the oocyte. These cells define, in the underlying posterior oocyte cortex, the anchoring of the germ cell determinant oskar mRNA. We reveal that the apical surface of these posterior anchoring cells extends long filopodia penetrating the oocyte. We identify two JAK-STAT targets in these cells that are each sufficient to extend the zone of contact with the oocyte, thereby leading to production of extra primordial germ cells. JAK-STAT signaling thus determines a fixed number of posterior anchoring cells required for anterior-posterior oocyte polarity and for the development of the future germline.

Date: 2024
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DOI: 10.1038/s41467-024-45963-z

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