Heterogeneity of synaptic connectivity in the fly visual system

Jacqueline Cornean, Sebastian Molina-Obando, Burak Gür, Annika Bast, Giordano Ramos-Traslosheros, Jonas Chojetzki, Lena Lörsch, Maria Ioannidou, Rachita Taneja, Christopher Schnaitmann and Marion Silies ()
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Jacqueline Cornean: Johannes-Gutenberg University
Sebastian Molina-Obando: Johannes-Gutenberg University
Burak Gür: Johannes-Gutenberg University
Annika Bast: Johannes-Gutenberg University
Giordano Ramos-Traslosheros: Johannes-Gutenberg University
Jonas Chojetzki: Johannes-Gutenberg University
Lena Lörsch: Johannes-Gutenberg University
Maria Ioannidou: Johannes-Gutenberg University
Rachita Taneja: Johannes-Gutenberg University
Christopher Schnaitmann: Johannes-Gutenberg University
Marion Silies: Johannes-Gutenberg University

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract Visual systems are homogeneous structures, where repeating columnar units retinotopically cover the visual field. Each of these columns contain many of the same neuron types that are distinguished by anatomic, genetic and – generally – by functional properties. However, there are exceptions to this rule. In the 800 columns of the Drosophila eye, there is an anatomically and genetically identifiable cell type with variable functional properties, Tm9. Since anatomical connectivity shapes functional neuronal properties, we identified the presynaptic inputs of several hundred Tm9s across both optic lobes using the full adult female fly brain (FAFB) electron microscopic dataset and FlyWire connectome. Our work shows that Tm9 has three major and many sparsely distributed inputs. This differs from the presynaptic connectivity of other Tm neurons, which have only one major, and more stereotypic inputs than Tm9. Genetic synapse labeling showed that the heterogeneous wiring exists across individuals. Together, our data argue that the visual system uses heterogeneous, distributed circuit properties to achieve robust visual processing.

Date: 2024
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DOI: 10.1038/s41467-024-45971-z

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