Cellular reprogramming as a tool to model human aging in a dish

Patricia R. Pitrez, Luis M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens () and Lino Ferreira ()
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Patricia R. Pitrez: University of Coimbra
Luis M. Monteiro: University of Coimbra
Oliver Borgogno: University of California San Diego
Xavier Nissan: CECS, I-STEM, AFM, Institute for Stem Cell Therapy and Exploration of Monogenic diseases
Jerome Mertens: University of California San Diego
Lino Ferreira: University of Coimbra

Nature Communications, 2024, vol. 15, issue 1, 1-11

Abstract: Abstract The design of human model systems is highly relevant to unveil the underlying mechanisms of aging and to provide insights on potential interventions to extend human health and life span. In this perspective, we explore the potential of 2D or 3D culture models comprising human induced pluripotent stem cells and transdifferentiated cells obtained from aged or age-related disorder-affected donors to enhance our understanding of human aging and to catalyze the discovery of anti-aging interventions.

Date: 2024
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DOI: 10.1038/s41467-024-46004-5

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