A wireless battery-free eye modulation patch for high myopia therapy

Tianyan Zhong, Hangjin Yi, Jiacheng Gou, Jie Li, Miao Liu, Xing Gao, Sizhu Chen, Hongye Guan, Shan Liang, Qianxiong He, Rui Lin, Zhihe Long, Yue Wang, Chuang Shi, Yang Zhan, Yan Zhang, Lili Xing, Jie Zhong () and Xinyu Xue ()
Additional contact information
Tianyan Zhong: University of Electronic Science and Technology of China
Hangjin Yi: University of Electronic Science and Technology of China
Jiacheng Gou: University of Electronic Science and Technology of China
Jie Li: Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Miao Liu: Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Xing Gao: Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Sizhu Chen: Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Hongye Guan: University of Electronic Science and Technology of China
Shan Liang: University of Electronic Science and Technology of China
Qianxiong He: University of Electronic Science and Technology of China
Rui Lin: University of Electronic Science and Technology of China
Zhihe Long: City University of Hong Kong
Yue Wang: University of Electronic Science and Technology of China
Chuang Shi: University of Electronic Science and Technology of China
Yang Zhan: Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences
Yan Zhang: University of Electronic Science and Technology of China
Lili Xing: University of Electronic Science and Technology of China
Jie Zhong: University of Electronic Science and Technology of China
Xinyu Xue: University of Electronic Science and Technology of China

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract The proper axial length of the eye is crucial for achieving emmetropia. In this study, we present a wireless battery-free eye modulation patch designed to correct high myopia and prevent relapse. The patch consists of piezoelectric transducers, an electrochemical micro-actuator, a drug microneedle array, μ-LEDs, a flexible circuit, and biocompatible encapsulation. The system can be wirelessly powered and controlled using external ultrasound. The electrochemical micro-actuator plays a key role in precisely shortening the axial length by driving the posterior sclera inward. This ensures accurate scene imaging on the retina for myopia eye. The drug microneedle array delivers riboflavin to the posterior sclera, and μ-LEDs’ blue light induces collagen cross-linking, reinforcing sclera strength. In vivo experiments demonstrate that the patch successfully reduces the rabbit eye’s axial length by ~1217 μm and increases sclera strength by 387%. The system operates effectively within the body without the need for batteries. Here, we show that the patch offers a promising avenue for clinically treating high myopia.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-46049-6 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46049-6

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-46049-6

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().