A persistent prefrontal reference frame across time and task rules

Hannah Muysers, Hung-Ling Chen, Johannes Hahn, Shani Folschweiller, Torfi Sigurdsson, Jonas-Frederic Sauer () and Marlene Bartos ()
Additional contact information
Hannah Muysers: Albert-Ludwigs-University Freiburg
Hung-Ling Chen: Albert-Ludwigs-University Freiburg
Johannes Hahn: Goethe University Frankfurt
Shani Folschweiller: Albert-Ludwigs-University Freiburg
Torfi Sigurdsson: Goethe University Frankfurt
Jonas-Frederic Sauer: Albert-Ludwigs-University Freiburg
Marlene Bartos: Albert-Ludwigs-University Freiburg

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Behavior can be remarkably consistent, even over extended time periods, yet whether this is reflected in stable or ‘drifting’ neuronal responses to task features remains controversial. Here, we find a persistently active ensemble of neurons in the medial prefrontal cortex (mPFC) of mice that reliably maintains trajectory-specific tuning over several weeks while performing an olfaction-guided spatial memory task. This task-specific reference frame is stabilized during learning, upon which repeatedly active neurons show little representational drift and maintain their trajectory-specific tuning across long pauses in task exposure and across repeated changes in cue-target location pairings. These data thus suggest a ‘core ensemble’ of prefrontal neurons forming a reference frame of task-relevant space for the performance of consistent behavior over extended periods of time.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-46350-4 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46350-4

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-46350-4

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().