Population-wide cerebellar growth models of children and adolescents

Carolin Gaiser, Rick Vliet, Augustijn A. A. Boer, Opher Donchin, Pierre Berthet, Gabriel A. Devenyi, M. Mallar Chakravarty, Jörn Diedrichsen, Andre F. Marquand, Maarten A. Frens () and Ryan L. Muetzel
Additional contact information
Carolin Gaiser: University Medical Centre Rotterdam
Rick Vliet: University Medical Centre Rotterdam
Augustijn A. A. Boer: Radboud University Nijmegen
Opher Donchin: Ben-Gurion University of the Negev
Pierre Berthet: University of Oslo
Gabriel A. Devenyi: McGill University
M. Mallar Chakravarty: McGill University
Jörn Diedrichsen: Western University
Andre F. Marquand: Radboud University Nijmegen
Maarten A. Frens: University Medical Centre Rotterdam
Ryan L. Muetzel: University Medical Centre Rotterdam

Nature Communications, 2024, vol. 15, issue 1, 1-15

Abstract: Abstract In the past, the cerebellum has been best known for its crucial role in motor function. However, increasingly more findings highlight the importance of cerebellar contributions in cognitive functions and neurodevelopment. Using a total of 7240 neuroimaging scans from 4862 individuals, we describe and provide detailed, openly available models of cerebellar development in childhood and adolescence (age range: 6–17 years), an important time period for brain development and onset of neuropsychiatric disorders. Next to a traditionally used anatomical parcellation of the cerebellum, we generated growth models based on a recently proposed functional parcellation. In both, we find an anterior-posterior growth gradient mirroring the age-related improvements of underlying behavior and function, which is analogous to cerebral maturation patterns and offers evidence for directly related cerebello-cortical developmental trajectories. Finally, we illustrate how the current approach can be used to detect cerebellar abnormalities in clinical samples.

Date: 2024
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DOI: 10.1038/s41467-024-46398-2

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