Tissue engineered vascular grafts are resistant to the formation of dystrophic calcification

Mackenzie E. Turner, Kevin M. Blum, Tatsuya Watanabe, Erica L. Schwarz, Mahboubeh Nabavinia, Joseph T. Leland, Delaney J. Villarreal, William E. Schwartzman, Ting-Heng Chou, Peter B. Baker, Goki Matsumura, Rajesh Krishnamurthy, Andrew R. Yates, Kan N. Hor, Jay D. Humphrey, Alison L. Marsden, Mitchel R. Stacy, Toshiharu Shinoka and Christopher K. Breuer ()
Additional contact information
Mackenzie E. Turner: Research Institute at Nationwide Children’s Hospital
Kevin M. Blum: Research Institute at Nationwide Children’s Hospital
Tatsuya Watanabe: Research Institute at Nationwide Children’s Hospital
Erica L. Schwarz: Yale University
Mahboubeh Nabavinia: Research Institute at Nationwide Children’s Hospital
Joseph T. Leland: Research Institute at Nationwide Children’s Hospital
Delaney J. Villarreal: Research Institute at Nationwide Children’s Hospital
William E. Schwartzman: Research Institute at Nationwide Children’s Hospital
Ting-Heng Chou: Research Institute at Nationwide Children’s Hospital
Peter B. Baker: Pathology Department at Nationwide Children’s Hospital and The Ohio State University
Goki Matsumura: Tokyo Women’s Medical University
Rajesh Krishnamurthy: Nationwide Children’s Hospital and The Ohio State University
Andrew R. Yates: The Ohio State University College of Medicine
Kan N. Hor: The Ohio State University College of Medicine
Jay D. Humphrey: Yale University
Alison L. Marsden: Stanford University
Mitchel R. Stacy: Research Institute at Nationwide Children’s Hospital
Toshiharu Shinoka: Research Institute at Nationwide Children’s Hospital
Christopher K. Breuer: Research Institute at Nationwide Children’s Hospital

Nature Communications, 2024, vol. 15, issue 1, 1-10

Abstract: Abstract Advancements in congenital heart surgery have heightened the importance of durable biomaterials for adult survivors. Dystrophic calcification poses a significant risk to the long-term viability of prosthetic biomaterials in these procedures. Herein, we describe the natural history of calcification in the most frequently used vascular conduits, expanded polytetrafluoroethylene grafts. Through a retrospective clinical study and an ovine model, we compare the degree of calcification between tissue-engineered vascular grafts and polytetrafluoroethylene grafts. Results indicate superior durability in tissue-engineered vascular grafts, displaying reduced late-term calcification in both clinical studies (p

Date: 2024
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DOI: 10.1038/s41467-024-46431-4

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