Uptake of COVID-19 vaccinations amongst 3,433,483 children and young people: meta-analysis of UK prospective cohorts

Sarah J. Aldridge (), Utkarsh Agrawal, Siobhán Murphy, Tristan Millington, Ashley Akbari, Fatima Almaghrabi, Sneha N. Anand, Stuart Bedston, Rosalind Goudie, Rowena Griffiths, Mark Joy, Emily Lowthian, Simon Lusignan, Lynsey Patterson, Chris Robertson, Igor Rudan, Declan T. Bradley, Ronan A. Lyons, Aziz Sheikh and Rhiannon K. Owen ()
Additional contact information
Sarah J. Aldridge: Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University
Utkarsh Agrawal: University of Oxford
Siobhán Murphy: School of Medicine, Dentistry and Biomedical Sciences, Queen’s University
Tristan Millington: University of Edinburgh
Ashley Akbari: Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University
Fatima Almaghrabi: University of Edinburgh
Sneha N. Anand: University of Oxford
Stuart Bedston: Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University
Rosalind Goudie: University of Oxford
Rowena Griffiths: Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University
Mark Joy: University of Oxford
Emily Lowthian: School of Social Sciences, Swansea University
Simon Lusignan: University of Oxford
Lynsey Patterson: School of Medicine, Dentistry and Biomedical Sciences, Queen’s University
Chris Robertson: Strathclyde University, Glasgow, UK and Public Health Scotland
Igor Rudan: Usher Institute, the University of Edinburgh
Declan T. Bradley: School of Medicine, Dentistry and Biomedical Sciences, Queen’s University
Ronan A. Lyons: Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University
Aziz Sheikh: University of Oxford
Rhiannon K. Owen: Swansea University Medical School, Faculty of Medicine, Health, and Life Science, Swansea University

Nature Communications, 2024, vol. 15, issue 1, 1-12

Abstract: Abstract SARS-CoV-2 infection in children and young people (CYP) can lead to life-threatening COVID-19, transmission within households and schools, and the development of long COVID. Using linked health and administrative data, we investigated vaccine uptake among 3,433,483 CYP aged 5–17 years across all UK nations between 4th August 2021 and 31st May 2022. We constructed national cohorts and undertook multi-state modelling and meta-analysis to identify associations between demographic variables and vaccine uptake. We found that uptake of the first COVID-19 vaccine among CYP was low across all four nations compared to other age groups and diminished with subsequent doses. Age and vaccination status of adults living in the same household were identified as important risk factors associated with vaccine uptake in CYP. For example, 5–11 year-olds were less likely to receive their first vaccine compared to 16–17 year-olds (adjusted Hazard Ratio [aHR]: 0.10 (95%CI: 0.06–0.19)), and CYP in unvaccinated households were less likely to receive their first vaccine compared to CYP in partially vaccinated households (aHR: 0.19, 95%CI 0.13–0.29).

Date: 2024
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DOI: 10.1038/s41467-024-46451-0

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