Impact of vaccination on the association of COVID-19 with cardiovascular diseases: An OpenSAFELY cohort study

Genevieve I. Cezard, Rachel E. Denholm, Rochelle Knight, Yinghui Wei, Lucy Teece, Renin Toms, Harriet J. Forbes, Alex J. Walker, Louis Fisher, Jon Massey, Lisa E. M. Hopcroft, Elsie M. F. Horne, Kurt Taylor, Tom Palmer, Marwa Al Arab, Jose Ignacio Cuitun Coronado, Samantha H. Y. Ip, Simon Davy, Iain Dillingham, Sebastian Bacon, Amir Mehrkar, Caroline E. Morton, Felix Greaves, Catherine Hyams, George Davey Smith, John Macleod, Nishi Chaturvedi, Ben Goldacre, William N. Whiteley, Angela M. Wood, Jonathan A. C. Sterne () and Venexia Walker
Additional contact information
Genevieve I. Cezard: University of Cambridge
Rachel E. Denholm: University of Bristol
Rochelle Knight: University of Bristol
Yinghui Wei: University of Plymouth
Lucy Teece: University of Leicester
Renin Toms: University of Bristol
Harriet J. Forbes: London School of Hygiene & tropical Medicine
Alex J. Walker: University of Oxford
Louis Fisher: University of Oxford
Jon Massey: University of Oxford
Lisa E. M. Hopcroft: NHS National Services Scotland
Elsie M. F. Horne: University of Bristol
Kurt Taylor: University of Bristol
Tom Palmer: University of Bristol
Marwa Al Arab: University of Bristol
Jose Ignacio Cuitun Coronado: University of Bristol
Samantha H. Y. Ip: University of Cambridge
Simon Davy: University of Oxford
Iain Dillingham: University of Oxford
Sebastian Bacon: University of Oxford
Amir Mehrkar: University of Oxford
Caroline E. Morton: Queen Mary University of London
Felix Greaves: National Institute for Health and Care Excellence
Catherine Hyams: University of Bristol
George Davey Smith: University of Bristol
John Macleod: University of Bristol
Nishi Chaturvedi: University College London
Ben Goldacre: University of Oxford
William N. Whiteley: University of Edinburgh
Angela M. Wood: University of Cambridge
Jonathan A. C. Sterne: University of Bristol
Venexia Walker: University of Bristol

Nature Communications, 2024, vol. 15, issue 1, 1-14

Abstract: Abstract Infection with SARS-CoV-2 is associated with an increased risk of arterial and venous thrombotic events, but the implications of vaccination for this increased risk are uncertain. With the approval of NHS England, we quantified associations between COVID-19 diagnosis and cardiovascular diseases in different vaccination and variant eras using linked electronic health records for ~40% of the English population. We defined a ‘pre-vaccination’ cohort (18,210,937 people) in the wild-type/Alpha variant eras (January 2020-June 2021), and ‘vaccinated’ and ‘unvaccinated’ cohorts (13,572,399 and 3,161,485 people respectively) in the Delta variant era (June-December 2021). We showed that the incidence of each arterial thrombotic, venous thrombotic and other cardiovascular outcomes was substantially elevated during weeks 1-4 after COVID-19, compared with before or without COVID-19, but less markedly elevated in time periods beyond week 4. Hazard ratios were higher after hospitalised than non-hospitalised COVID-19 and higher in the pre-vaccination and unvaccinated cohorts than the vaccinated cohort. COVID-19 vaccination reduces the risk of cardiovascular events after COVID-19 infection. People who had COVID-19 before or without being vaccinated are at higher risk of cardiovascular events for at least two years.

Date: 2024
References: View references in EconPapers View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/s41467-024-46497-0 Abstract (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46497-0

Ordering information: This journal article can be ordered from
https://www.nature.com/ncomms/

DOI: 10.1038/s41467-024-46497-0

Access Statistics for this article

Nature Communications is currently edited by Nathalie Le Bot, Enda Bergin and Fiona Gillespie

More articles in Nature Communications from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().