Neuropathogenesis-on-chips for neurodegenerative diseases

Sarnai Amartumur, Huong Nguyen, Thuy Huynh, Testaverde S. Kim, Ran-Sook Woo, Eungseok Oh, Kyeong Kyu Kim, Luke P. Lee () and Chaejeong Heo ()
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Sarnai Amartumur: Sungkyunkwan University
Huong Nguyen: Sungkyunkwan University
Thuy Huynh: Sungkyunkwan University
Testaverde S. Kim: Institute for Basic Science (IBS)
Ran-Sook Woo: Eulji University
Eungseok Oh: Chungnam National University Hospital
Kyeong Kyu Kim: Sungkyunkwan University School of Medicine
Luke P. Lee: Sungkyunkwan University
Chaejeong Heo: Sungkyunkwan University

Nature Communications, 2024, vol. 15, issue 1, 1-34

Abstract: Abstract Developing diagnostics and treatments for neurodegenerative diseases (NDs) is challenging due to multifactorial pathogenesis that progresses gradually. Advanced in vitro systems that recapitulate patient-like pathophysiology are emerging as alternatives to conventional animal-based models. In this review, we explore the interconnected pathogenic features of different types of ND, discuss the general strategy to modelling NDs using a microfluidic chip, and introduce the organoid-on-a-chip as the next advanced relevant model. Lastly, we overview how these models are being applied in academic and industrial drug development. The integration of microfluidic chips, stem cells, and biotechnological devices promises to provide valuable insights for biomedical research and developing diagnostic and therapeutic solutions for NDs.

Date: 2024
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DOI: 10.1038/s41467-024-46554-8

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